Potential Relationship between Clinical Significance and Serum Exosomal miRNAs in Patients with Multiple Myeloma
Joint Authors
Zhang, Zhi-yao
Li, Yan-chen
Geng, Chuan-ying
Wang, Hui-juan
Chen, Wen-ming
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study evaluated the potential relationship between exosomal miRNAs and clinical symptoms in patients with multiple myeloma (MM).
Forty-eight newly diagnosed myeloma patients and sixteen normal donors were enrolled in the study.
The results showed that the relative expression levels of let-7c-5p, let-7d-5p, miR-140-3p, miR-185-5p, and miR-425-5p in the exosomes of MM patients were significantly lower than those of healthy controls.
Furthermore, there were significant differences in the clinical characteristics of myeloma, such as kidney damage, while the expression levels of the same miRNA in exosomes and serum are not correlated.
The expression of exosomal miRNA is related to the expression levels of clinical feature-related factors, such as creatinine, β2-microglobulin, β-CTX, and IL-6 in serum.
Establishing this relationship could contribute to understanding the pathogenesis of MM.
American Psychological Association (APA)
Zhang, Zhi-yao& Li, Yan-chen& Geng, Chuan-ying& Wang, Hui-juan& Chen, Wen-ming. 2019. Potential Relationship between Clinical Significance and Serum Exosomal miRNAs in Patients with Multiple Myeloma. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123416
Modern Language Association (MLA)
Zhang, Zhi-yao…[et al.]. Potential Relationship between Clinical Significance and Serum Exosomal miRNAs in Patients with Multiple Myeloma. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1123416
American Medical Association (AMA)
Zhang, Zhi-yao& Li, Yan-chen& Geng, Chuan-ying& Wang, Hui-juan& Chen, Wen-ming. Potential Relationship between Clinical Significance and Serum Exosomal miRNAs in Patients with Multiple Myeloma. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123416