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Development and Validation of a Novel Model to Predict Liver Histopathology in Patients with Chronic Hepatitis B
Joint Authors
Guo, Hongying
Zhu, Beidi
Li, Shu
Li, Jing
Shen, Zhiqing
Zheng, Yijuan
Zhao, Weidong
Tan, Dan
Wu, Jingwen
Zhang, Xueyun
Jiang, Qirong
Qi, Xun
Mao, Richeng
Yu, Xueping
Su, Zhijun
Zhang, Jiming
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
It is still vague for chronic hepatitis B (CHB) patients with normal or mildly increasing alanine aminotransferase (ALT) level to undergo antiviral treatment or not.
The purpose of our study was to establish a noninvasive model based on routine blood test to predict liver histopathology for antiviral therapy.
This retrospective study enrolled 258 CHB patients with liver biopsy from the First Hospital of Quanzhou (training cohort, n=126) and Huashan Hospital (validation cohort, n=132).
Histologic grading of necroinflammation (G) and liver fibrosis (S) was performed according to the Scheuer scoring system.
A novel model, ATPI, including aspartate aminotransferase (AST), total bilirubin (TBil), and platelets (PLT), was developed in training cohort.
The area under ROC curves (AUC) of ATPI for predicting antiviral therapy indication was 0.83 in training cohort and was 0.88 in the validation cohort, respectively.
Similarly, ATPI also displayed the highest AUC in predicting antiviral therapy indication in CHB patients with normal or mildly increasing ALT level.
In conclusion, ATPI is a novel independent model to predict liver histopathology for antiviral therapy in CHB patients with normal and mildly increased ALT levels.
American Psychological Association (APA)
Guo, Hongying& Zhu, Beidi& Li, Shu& Li, Jing& Shen, Zhiqing& Zheng, Yijuan…[et al.]. 2019. Development and Validation of a Novel Model to Predict Liver Histopathology in Patients with Chronic Hepatitis B. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123436
Modern Language Association (MLA)
Guo, Hongying…[et al.]. Development and Validation of a Novel Model to Predict Liver Histopathology in Patients with Chronic Hepatitis B. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1123436
American Medical Association (AMA)
Guo, Hongying& Zhu, Beidi& Li, Shu& Li, Jing& Shen, Zhiqing& Zheng, Yijuan…[et al.]. Development and Validation of a Novel Model to Predict Liver Histopathology in Patients with Chronic Hepatitis B. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123436
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123436