Exosomes in Cancer: Circulating Immune-Related Biomarkers
Joint Authors
Szczepanski, Miroslaw J.
Głuszko, Alicja
Ludwig, Nils
Mirza, Shafaq M.
Olejarz, Wioletta
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Exosomes, the smallest vesicles (30–100 nm) among multivesicular bodies, are released by all body cells including tumor cells.
The cargo they transfer plays an important role in intercellular communication.
Tumor-derived exosomes (TEXs) maintain interactions between cancer cells and the microenvironment.
Emerging evidence suggests that tumor cells release a large number of exosomes, which may not only influence proximal tumor cells and stromal cells in the local microenvironment but can also exert systemic effects as they are circulating in the blood.
TEXs have been shown to boost tumor growth promote progression and metastatic spread via suppression or modification of the immune response towards cancer cells, regulation of tumor neo-angiogenesis, pre-metastatic niche formation, and therapy resistance.
In addition, recent studies in patients with cancer suggest that TEXs could serve as tumor biomarker reflecting partially the genetic and molecular content of the parent cancer cell (i.e., as a so-called “liquid biopsy”).
Furthermore, recent studies have demonstrated that exosomes may have immunotherapeutic applications, or can act as a drug delivery system for targeted therapies with drugs and biomolecules.
American Psychological Association (APA)
Głuszko, Alicja& Szczepanski, Miroslaw J.& Ludwig, Nils& Mirza, Shafaq M.& Olejarz, Wioletta. 2019. Exosomes in Cancer: Circulating Immune-Related Biomarkers. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123441
Modern Language Association (MLA)
Głuszko, Alicja…[et al.]. Exosomes in Cancer: Circulating Immune-Related Biomarkers. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1123441
American Medical Association (AMA)
Głuszko, Alicja& Szczepanski, Miroslaw J.& Ludwig, Nils& Mirza, Shafaq M.& Olejarz, Wioletta. Exosomes in Cancer: Circulating Immune-Related Biomarkers. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123441
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123441