Antiapoptosis and Antifibrosis Effects of Qishen Granules on Heart Failure Rats via Hippo Pathway
Joint Authors
Wang, Wei
Zhu, Ruixin
Zhang, Jian
Liu, Junjie
Gao, Sheng
Lin, Weili
Gao, Pengrong
Gao, Kuo
Zhang, Yili
Du, Kangjia
Yang, Xiaomin
Wang, Yong
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Qishen granules (QSG) are a famous formula with cardioprotective properties to heart failure (HF).
The aim of this study was to investigate the underlying mechanism of QSG on apoptosis and fibrosis in the treatment of HF.
HF model was induced by left anterior descending artery ligation on Sprague-Dawley rats.
Transcriptome analysis was used to investigate the regulatory pathways of QSG on HF.
Interestingly, downregulated genes of QSG were significantly enriched in Hippo pathway which plays a crucial role in regulating cell apoptosis and proliferation.
We found that QSG inhibited the expressions of proapoptotic key proteins P-53 and fibrosis-related proteins TGF-β1, SMAD3, and CTGF.
Further, we conducted research on the key proteins in the Hippo pathway upstream of CTGF and P-53.
The results showed that MST1, P-MST1, P-LATS1, and RASSF1A that exert proapoptotic function were downregulated after QSG intervention.
Similarly, P-YAP and P-TAZ, mediating self-degradation and apoptosis, were both observably decreased after QSG administration.
Taken together, QSG are shown to be likely to exert cardioprotective effects by inhibiting the progression of apoptosis and fibrosis through Hippo pathway.
American Psychological Association (APA)
Zhang, Jian& Liu, Junjie& Gao, Sheng& Lin, Weili& Gao, Pengrong& Gao, Kuo…[et al.]. 2019. Antiapoptosis and Antifibrosis Effects of Qishen Granules on Heart Failure Rats via Hippo Pathway. BioMed Research International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1123445
Modern Language Association (MLA)
Zhang, Jian…[et al.]. Antiapoptosis and Antifibrosis Effects of Qishen Granules on Heart Failure Rats via Hippo Pathway. BioMed Research International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1123445
American Medical Association (AMA)
Zhang, Jian& Liu, Junjie& Gao, Sheng& Lin, Weili& Gao, Pengrong& Gao, Kuo…[et al.]. Antiapoptosis and Antifibrosis Effects of Qishen Granules on Heart Failure Rats via Hippo Pathway. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1123445
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123445