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Combination of Fresh Frozen Plasma and Cryosupernatant Plasma for Therapeutic Plasma Exchange in Thrombotic Thrombocytopenic Purpura: A Single Institution Experience
Joint Authors
Lin, Qiuyan
Fan, Liping
Huang, Haobo
Zeng, Feng
Fu, Danhui
Wei, Shijin
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
To evaluate the impact of a combination of fresh frozen plasma (FFP) and cryosupernatant plasma (CP) as a replacement fluid in therapeutic plasma exchange (TPE) on early therapeutic response and long-term survival of patients with thrombotic thrombocytopenic purpura (TTP).
Materials and Methods.
A total of 44 patients with suspected TTP were screened by Bentley and PLASMIC scores.
Twenty-seven patients treated with TPE using the FFP and CP combination as the replacement fluid were enrolled and divided into two groups: 11 patients who received TPE with CP-dominant replacement fluid (FFP/CP<1) and 16 patients who received TPE with FFP-dominant replacement fluid (FFP/CP>1).
Results.
There were no significant differences in the demographic and clinicopathological characteristics between the two groups except for the international normalized ratio (INR).
The number of TPE procedures was lower, and time to achieve complete response was shorter in the CP-dominant group than in the FFP-dominant group.
There were no significant differences in overall survival between the two groups.
Conclusion.
The CP-dominant replacement fluid was superior to the FFP-dominant replacement fluid in early response to TPE in patients with TTP, but did not impact the patients’ overall survival.
American Psychological Association (APA)
Lin, Qiuyan& Fan, Liping& Huang, Haobo& Zeng, Feng& Fu, Danhui& Wei, Shijin. 2019. Combination of Fresh Frozen Plasma and Cryosupernatant Plasma for Therapeutic Plasma Exchange in Thrombotic Thrombocytopenic Purpura: A Single Institution Experience. BioMed Research International،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1123492
Modern Language Association (MLA)
Lin, Qiuyan…[et al.]. Combination of Fresh Frozen Plasma and Cryosupernatant Plasma for Therapeutic Plasma Exchange in Thrombotic Thrombocytopenic Purpura: A Single Institution Experience. BioMed Research International No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1123492
American Medical Association (AMA)
Lin, Qiuyan& Fan, Liping& Huang, Haobo& Zeng, Feng& Fu, Danhui& Wei, Shijin. Combination of Fresh Frozen Plasma and Cryosupernatant Plasma for Therapeutic Plasma Exchange in Thrombotic Thrombocytopenic Purpura: A Single Institution Experience. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1123492
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123492