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Effect of Lonicera caerulea var. emphyllocalyx Extracts on Murine Streptococcus pyogenes Infection by Modulating Immune System
Joint Authors
Minami, Masaaki
Nakamura, Mineo
Makino, Toshiaki
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Streptococcus pyogenes (S.
pyogenes) causes several infectious diseases such as tonsillitis, cellulitis, and streptococcal toxic shock syndrome.
The general treatment of S.
pyogenes infection is by using β-lactam antibiotics; however, the cases of treatment failure were increasing as serious problems.
Lonicera caerulea var.
emphyllocalyx (LCE) has been used in the folk medicine in the northern part of Japan, the northern part of China, Korea, and Russia.
In this study, we investigated the efficacy of three parts (fruit, stem, and leaf) of Lonicera caerulea var.
emphyllocalyx extract (LCEEs) against murine S.
pyogenes infection.
Oral administration of LCEEs increased the mortality in murine model, and the extracts of its stems and leaves were more effective than the fruit extract significantly.
Murine splenocytes and mesenteric lymph nodal cells treated with LCEEs suppressed the excess production of inflammatory cytokine such as TNF-α in comparison to those from untreated cells.
LCEEs stimulated the differentiation of pluripotent hematopoietic stem cells in those murine lymph nodal cells.
It also activated the proliferative response of murine lymph nodal cells.
We also found that the stem and leaf extracts seemed to be more effective than the fruit extract in those phenomena.
The concentration of lignins in LCEE prepared from the stems was larger than that from leaves, and that was larger than that from the fruits.
Our data suggest that LCE, especially the stems and the leaves, may be useful for the treatment of S.
pyogenes infection.
American Psychological Association (APA)
Minami, Masaaki& Nakamura, Mineo& Makino, Toshiaki. 2019. Effect of Lonicera caerulea var. emphyllocalyx Extracts on Murine Streptococcus pyogenes Infection by Modulating Immune System. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1123511
Modern Language Association (MLA)
Minami, Masaaki…[et al.]. Effect of Lonicera caerulea var. emphyllocalyx Extracts on Murine Streptococcus pyogenes Infection by Modulating Immune System. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1123511
American Medical Association (AMA)
Minami, Masaaki& Nakamura, Mineo& Makino, Toshiaki. Effect of Lonicera caerulea var. emphyllocalyx Extracts on Murine Streptococcus pyogenes Infection by Modulating Immune System. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1123511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123511