Anti-Inflammatory Activities of Leaf Oil from Cinnamomum subavenium In Vitro and In Vivo
Joint Authors
Zhang, Yonghui
Wang, Xuanbin
Hao, Xincai
Sun, Weiguang
Ke, Changbin
Wang, Fuqian
Xue, Yongbo
Luo, Zengwei
Zhang, Jinwen
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The study determined the chemical constituents and anti-inflammatory effects of leaf oil from Cinnamomum subavenium (CS-LO) that has been used in folk medicine to treat various symptoms including inflammation.
The anti-inflammatory effects of the oil were evaluated by LPS-stimulated RAW264.7 cells and the Carr-induced hind mouse paw edema model, respectively.
In vitro, nitric oxide (NO), prostaglandin E2 (PGE2), TNF-α, IL-6, and IL-1β were significantly decreased by CS-LO, and the expression of nuclear factor-κB (NF-κB) protein was blocked as well.
In in vivo, the malondialdehyde (MDA) and paw edema levels were decreased by CS-LO, and the same result came up on the NO and tumor necrosis factor (TNF-a) of serum at the 5th h after Carr injection.
In addition, iNOS and COX-2 immunoreactive cells of the paw tissue were decreased significantly by CS-LO (200 mg/kg) in histological examination.
The present findings indicated that CS-LO have anti-inflammatory properties, and the effects might be caused through inhibiting iNOS, COX-2, TNF-α, IL-1β, and IL-6 expression via affecting NF-κB pathway, which will provide a power scientific basis for CS-LO to be used as the treatment of inflammatory diseases.
American Psychological Association (APA)
Hao, Xincai& Sun, Weiguang& Ke, Changbin& Wang, Fuqian& Xue, Yongbo& Luo, Zengwei…[et al.]. 2019. Anti-Inflammatory Activities of Leaf Oil from Cinnamomum subavenium In Vitro and In Vivo. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1123524
Modern Language Association (MLA)
Hao, Xincai…[et al.]. Anti-Inflammatory Activities of Leaf Oil from Cinnamomum subavenium In Vitro and In Vivo. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1123524
American Medical Association (AMA)
Hao, Xincai& Sun, Weiguang& Ke, Changbin& Wang, Fuqian& Xue, Yongbo& Luo, Zengwei…[et al.]. Anti-Inflammatory Activities of Leaf Oil from Cinnamomum subavenium In Vitro and In Vivo. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1123524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123524