Lycorine Hydrochloride Inhibits the Virulence Traits of Candida albicans
Joint Authors
Ma, Tonghui
Sui, Yujie
Yang, Longfei
Liu, Xin
Ma, Zhiming
Feng, Xuechao
Wang, Fang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The human opportunistic fungal pathogen Candida albicans causes a severe health burden while the biofilms formed by C.
albicans present a kind of infections that are hard to cure, highlighting the pressing need for new antifungal drugs against C.
albicans.
This study was to explore the antifungal activities of lycorine hydrochloride (LH) against C.
albicans.
The minimal inhibitory concentration (MIC) of LH against C.
albicans SC5314 was 64 μM.
Below its MIC, LH demonstrated antivirulence property by suppressing adhesion, filamentation, biofilm formation, and development, as well as the production of extracellular phospholipase and exopolymeric substances (EPS).
The cytotoxicity of LH against mammalian cells was low, with half maximal inhibitory concentrations (IC50) above 256 μM.
Moreover, LH showed a synergistic effect with AmB, although its interaction with fluconazole, as well as caspofungin, was indifferent.
Thus, our study reports the potential use of LH, alone or in combination with current antifungal drugs, to fight C.
albicans infections.
American Psychological Association (APA)
Yang, Longfei& Liu, Xin& Sui, Yujie& Ma, Zhiming& Feng, Xuechao& Wang, Fang…[et al.]. 2019. Lycorine Hydrochloride Inhibits the Virulence Traits of Candida albicans. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1123541
Modern Language Association (MLA)
Yang, Longfei…[et al.]. Lycorine Hydrochloride Inhibits the Virulence Traits of Candida albicans. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1123541
American Medical Association (AMA)
Yang, Longfei& Liu, Xin& Sui, Yujie& Ma, Zhiming& Feng, Xuechao& Wang, Fang…[et al.]. Lycorine Hydrochloride Inhibits the Virulence Traits of Candida albicans. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1123541
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123541