Manipulation of Intestinal Antiviral Innate Immunity and Immune Evasion Strategies of Porcine Epidemic Diarrhea Virus
Joint Authors
Du, Jian
Luo, Junqiu
Yu, Jie
Mao, Xiangbing
Luo, Yuheng
Zheng, Ping
He, Jun
Yu, Bing
Chen, Daiwen
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Porcine epidemic diarrhea virus (PEDV) infection causes watery diarrhea, dehydration, and high mortality in neonatal pigs, due to its clinical pathogenesis of the intestinal mucosal barrier dysfunction.
The host’s innate immune system is the first line of defence upon virus invasion of the small intestinal epithelial cells.
In turn, the virus has evolved to modulate the host’s innate immunity during infection, resulting in pathogen virulence, survival, and the establishment of successful infection.
In this review, we gather current knowledge concerning the interplay between PEDV and components of host innate immunity, focusing on the role of cytokines and interferons in intestinal antiviral innate immunity, and the mechanisms underlying the immune evasion strategies of PEDV invasion.
Finally, we provide some perspectives on the potential prevention and treatment for PEDV infection.
American Psychological Association (APA)
Du, Jian& Luo, Junqiu& Yu, Jie& Mao, Xiangbing& Luo, Yuheng& Zheng, Ping…[et al.]. 2019. Manipulation of Intestinal Antiviral Innate Immunity and Immune Evasion Strategies of Porcine Epidemic Diarrhea Virus. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123548
Modern Language Association (MLA)
Du, Jian…[et al.]. Manipulation of Intestinal Antiviral Innate Immunity and Immune Evasion Strategies of Porcine Epidemic Diarrhea Virus. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1123548
American Medical Association (AMA)
Du, Jian& Luo, Junqiu& Yu, Jie& Mao, Xiangbing& Luo, Yuheng& Zheng, Ping…[et al.]. Manipulation of Intestinal Antiviral Innate Immunity and Immune Evasion Strategies of Porcine Epidemic Diarrhea Virus. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123548
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123548