Neonatal Streptococcus pneumoniae Pneumonia Induces an Aberrant Airway Smooth Muscle Phenotype and AHR in Mice Model
Joint Authors
Peng, Xin
Wu, Yi
Kong, Xiao
Chen, Yunxiu
Tian, Yonglu
Li, Qinyuan
Tian, Xiaoyin
Zhang, Guangli
Ren, Luo
Luo, Zhengxiu
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Our previous study showed that neonatal S.
pneumoniae infection aggravated airway inflammation and airway hyperresponsiveness (AHR) in an OVA-induced allergic asthma model.
As airway smooth muscle (ASM) plays a pivotal role in AHR development, we aim to investigate the effects of neonatal S.
pneumoniae pneumonia on ASM structure and AHR development.
Non-lethal neonatal pneumonia was established by intranasally infecting 1-week-old BALB/C mice with the S.
pneumoniae strain D39.
Five weeks after infection, the lungs were collected to assess the levels of α-SMA and the contractile proteins of ASM.
Our results indicate that neonatal S.
pneumoniae pneumonia significantly increased adulthood lung α-SMA and SMMHC proteins production and aggravated airway inflammatory cells infiltration and cytokines release.
In addition, the neonatal S.
pneumoniae pneumonia group had significantly higher Penh values compared to the uninfected controls.
These data suggest that neonatal S.
pneumoniae pneumonia promoted an aberrant ASM phenotype and AHR development in mice model.
American Psychological Association (APA)
Peng, Xin& Wu, Yi& Kong, Xiao& Chen, Yunxiu& Tian, Yonglu& Li, Qinyuan…[et al.]. 2019. Neonatal Streptococcus pneumoniae Pneumonia Induces an Aberrant Airway Smooth Muscle Phenotype and AHR in Mice Model. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123586
Modern Language Association (MLA)
Peng, Xin…[et al.]. Neonatal Streptococcus pneumoniae Pneumonia Induces an Aberrant Airway Smooth Muscle Phenotype and AHR in Mice Model. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1123586
American Medical Association (AMA)
Peng, Xin& Wu, Yi& Kong, Xiao& Chen, Yunxiu& Tian, Yonglu& Li, Qinyuan…[et al.]. Neonatal Streptococcus pneumoniae Pneumonia Induces an Aberrant Airway Smooth Muscle Phenotype and AHR in Mice Model. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123586
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123586