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Exosomes in the Repair of Bone Defects: Next-Generation Therapeutic Tools for the Treatment of Nonunion
Joint Authors
Lu, Jian
Wang, Qi-Yang
Sheng, Jia-Gen
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Nonunion with bone defects, a common complication after long bone fracture, is a major challenge for orthopaedic surgeons worldwide because of the high incidence rate and difficulties in achieving successful treatment.
Bone defects are the main complications of nonunion.
The conventional biological treatments for nonunion with bone defects involve the use of autologous bone grafts or bone graft substitutes and cell-based therapy.
Traditional nonunion treatments have always been associated with safety issues and various other complications.
Bone grafts have limited autologous cancellous bone and there is a risk of infection.
Additionally, problems with bone graft substitutes, including rejection and stimulation of bone formation, have been noted, and the health of the stem cell niche is a major consideration in cell-based therapy.
In recent years, researchers have found that exosomes can be used to deliver functional RNA and mediate cell-to-cell communication, suggesting that exosomes may repair bone defects by regulating cells and cytokines involved in bone metabolism.
In this review, we highlight the possible relationships between risk factors for nonunion and exosomes.
Additionally, we discuss the roles of exosomes in bone metabolism and bone regeneration.
American Psychological Association (APA)
Lu, Jian& Wang, Qi-Yang& Sheng, Jia-Gen. 2019. Exosomes in the Repair of Bone Defects: Next-Generation Therapeutic Tools for the Treatment of Nonunion. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1123602
Modern Language Association (MLA)
Lu, Jian…[et al.]. Exosomes in the Repair of Bone Defects: Next-Generation Therapeutic Tools for the Treatment of Nonunion. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1123602
American Medical Association (AMA)
Lu, Jian& Wang, Qi-Yang& Sheng, Jia-Gen. Exosomes in the Repair of Bone Defects: Next-Generation Therapeutic Tools for the Treatment of Nonunion. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1123602
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123602