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Extract from Bougainvillea xbuttiana (Variety Orange) Inhibits Production of LPS-Induced Inflammatory Mediators in Macrophages and Exerts a Protective Effect In Vivo
Joint Authors
Abarca-Vargas, Rodolfo
Petricevich, Vera L.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Different pharmacological properties, such as antioxidant, antiproliferative, and anti-inflammatory properties, have been described among natural products.
We previously described that the Bougainvillea xbuttiana (Variety Orange) ethanolic extract (BxbO) has an anti-inflammatory effect; however, this action is not fully understood.
In this study, the action of the BxbO extract on the secretion of inflammatory mediators in two experimental models, in vitro and in vivo, after LPS challenge was evaluated.
Methods.
Peritoneal macrophages were obtained from female BALB/c mice and LPS-challenged with or without the BxbO extract.
For the evaluation of mediators, the supernatants at 0, 12, 24, 36, and 48 hours were collected.
For in vivo estimation, groups of female BALB/c mice were first intraperitoneously injected with different amounts of LPS and later administered the oral BxbO extract (v.o.) for 144 hours.
To understand the mechanism of action, sera obtained from mice were collected at 0, 2, 4, 8, 12, and 24 hours after LPS challenge (with or without BxbO) for the detection of mediators.
Results.
The results showed that, in both peritoneal macrophages and sera of mice treated with the BxbO extract 1 hour before or together with LPS challenge, proinflammatory cytokines and nitric oxide release were unquestionably repressed.
In contrast, in both systems studied here, the IL-10 levels were elevated to 5 to 9 times.
At lethal doses of LPS, the BxbO extract treatment was found to protect animals from death.
Conclusions.
The results revealed that the inhibitory, protective, and benign effects of the BxbO extract were due to its capacity to balance the secretion of mediators.
American Psychological Association (APA)
Abarca-Vargas, Rodolfo& Petricevich, Vera L.. 2019. Extract from Bougainvillea xbuttiana (Variety Orange) Inhibits Production of LPS-Induced Inflammatory Mediators in Macrophages and Exerts a Protective Effect In Vivo. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123619
Modern Language Association (MLA)
Abarca-Vargas, Rodolfo& Petricevich, Vera L.. Extract from Bougainvillea xbuttiana (Variety Orange) Inhibits Production of LPS-Induced Inflammatory Mediators in Macrophages and Exerts a Protective Effect In Vivo. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1123619
American Medical Association (AMA)
Abarca-Vargas, Rodolfo& Petricevich, Vera L.. Extract from Bougainvillea xbuttiana (Variety Orange) Inhibits Production of LPS-Induced Inflammatory Mediators in Macrophages and Exerts a Protective Effect In Vivo. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123619