Sodium Selenite Accentuates the Therapeutic Effect of Adriamycin Prodrug (PADM) against Gastric Cancer
Joint Authors
Tan, Shengquan
Mo, Jiapeng
Zhang, Zixiong
Huang, Chuying
Zou, Yi
Sun, Jianhua
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Selenium has remained a controversial character in cancer research.
While its antitumor effects have been widely demonstrated, further evidence is required to establish it as a robust treatment regime.
Sodium selenite (SS), an inorganic selenium, reportedly affected the proliferation and redifferentiation of gastric cancer cells, but whether it could act as a complement to conventional chemotherapeutic drugs for combination therapy is uncertain.
Herein, SGC-7901 and MGC-803 gastric cancer cells were treated with PADM (Ac-Phe-Lys-PABC-ADM), a prodrug of doxorubicin/adriamycin (ADM), and the combined antitumor effects of the two drugs were evaluated.
Characterization after treatment revealed that although PADM exhibited antitumor effects individually by inhibiting the proliferation and migration of gastric cancer cells and inducing apoptosis, the addition of SS significantly amplified these effects.
Furthermore, gastric cancer cell apoptosis triggered by the combined treatment of SS and PADM may involve the participation of mitochondrial apoptosis, as evidenced by the changes in mitochondrial morphology and occurrence of mitochondrial fission.
Collectively, SS could be a strong complementary drug that accentuates the therapeutic potential of PADM in gastric cancer treatment and management, and its significance could contribute to unique and innovative anticancer strategies.
American Psychological Association (APA)
Tan, Shengquan& Mo, Jiapeng& Zhang, Zixiong& Huang, Chuying& Zou, Yi& Sun, Jianhua. 2019. Sodium Selenite Accentuates the Therapeutic Effect of Adriamycin Prodrug (PADM) against Gastric Cancer. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1123623
Modern Language Association (MLA)
Tan, Shengquan…[et al.]. Sodium Selenite Accentuates the Therapeutic Effect of Adriamycin Prodrug (PADM) against Gastric Cancer. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1123623
American Medical Association (AMA)
Tan, Shengquan& Mo, Jiapeng& Zhang, Zixiong& Huang, Chuying& Zou, Yi& Sun, Jianhua. Sodium Selenite Accentuates the Therapeutic Effect of Adriamycin Prodrug (PADM) against Gastric Cancer. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1123623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123623