The Influence of Oxidative Stress and Natural Antioxidants on Morphometric Parameters of Red Blood Cells, the Hemoglobin Oxygen Binding Capacity, and the Activity of Antioxidant Enzymes

Abstract EN

Using a wide range of different physical and chemical methods, it was found that the oxidative stress caused by addition of hydrogen peroxide to the incubation medium has a significant effect on the conformation of haematoporphyrin, influencing the oxygen-binding properties of haemoglobin in red blood cells.

Morphofunctional characteristics of red blood cells change; in particular, we have observed the transformation of erythrocytes, their transition into echinocytes.

In erythrocytes, in response to increased lipid peroxidation (LPO) antioxidant enzymes become active.

The use of natural antioxidants (β-carotene and resveratrol) works towards reducting the level of oxidative processes.

Resveratrol has the greatest antioxidant effect.