Assessment of some genetic and environmental risk factors in patients with congenital heart diseases associated with pulmonary hypertension
Other Title(s)
تقييم بعض عوامل الخطورة الوراثية و البيئية في المرضى المصابين بأمراض القلب الخلقية المصوبة بارتفاع في ضغط الشريان الرئوي
Joint Authors
Muhammad, Amal
Rajab, Mustafa
al-Rubi, Muna
Abd Allah, Sali Gharib
Source
Journal of Environmental Science
Issue
Vol. 41, Issue 3 (31 Mar. 2018), pp.49-75, 27 p.
Publisher
Ain Shams University Institute of Environmental Studies and Rese Arch Accredited
Publication Date
2018-03-31
Country of Publication
Egypt
No. of Pages
27
Main Subjects
Topics
- Pregnancy
- Pregnant woman
- Counselling
- Mothers
- Marriage
- Medical care
- Childbirth
- Heart
- Diseases
- Diabetes
- Congenital malformations
- Complications(Medicine)
- Pulmonary hypertension
- Age
Abstract EN
Congenital heart disease (CHDs) -whether it is associated with pulmonary hypertension (PH) or not- is the most common malformation in children.
It is an important cause of infant mortality, long term morbidity and disability.
Aim of the study is to assess the role of some genetic and environmental risk factors in patients with CHDs associated with PH.
Subjects and methods: A case-control study was conducted and included 3 groups of cases; 37 patients with CHDs associated with PH, 37 patients with CHDs and 37 children without any congenital malformations were taken as a control group.
The following clinical information was collected through predesigned questionnaires: maternal age at conception; parental consanguinity; maternal gestational diabetes (DM) and hypertension, adverse reproductive history (abortions and still births); and maternal environmental tobacco smoking (ETS) and deficient folic acid intake during pregnancy.
Cytogenetic study for patients in the first and second groups of cases was carried out.
Results: Chromosomal abnormalities were detected in 13.5% of patients with CHDs associated with PH and 10.8% of patients with CHDs.
Maternal age, adverse reproductive history, maternal gestational DM and hypertension were not found to be significantly associated with congenital heart diseases in this study, while parental consanguinity, low maternal education level, maternal ETS and deficient folic acid intake during pregnancy were significantly associated with CHDs.
Conclusion: It is crucial to make proper decisions and implement policies for lowering consanguineous marriages and provide proper pre-marital counseling and improving antenatal care to control the cases of CHDs.
American Psychological Association (APA)
Rajab, Mustafa& al-Rubi, Muna& Muhammad, Amal& Abd Allah, Sali Gharib. 2018. Assessment of some genetic and environmental risk factors in patients with congenital heart diseases associated with pulmonary hypertension. Journal of Environmental Science،Vol. 41, no. 3, pp.49-75.
https://search.emarefa.net/detail/BIM-1123701
Modern Language Association (MLA)
Rajab, Mustafa…[et al.]. Assessment of some genetic and environmental risk factors in patients with congenital heart diseases associated with pulmonary hypertension. Journal of Environmental Science Vol. 41, no. 3 (Mar. 2018), pp.49-75.
https://search.emarefa.net/detail/BIM-1123701
American Medical Association (AMA)
Rajab, Mustafa& al-Rubi, Muna& Muhammad, Amal& Abd Allah, Sali Gharib. Assessment of some genetic and environmental risk factors in patients with congenital heart diseases associated with pulmonary hypertension. Journal of Environmental Science. 2018. Vol. 41, no. 3, pp.49-75.
https://search.emarefa.net/detail/BIM-1123701
Data Type
Journal Articles
Language
English
Notes
-
Record ID
BIM-1123701