Baicalin Protects against Thrombin-Induced Cell Injury in Human Umbilical Vein Endothelial Cells
Joint Authors
Zhang, Anna
Hou, Yunfeng
Sun, Chao
Pu, Ying
Sun, Yu
Zhang, Yuan
Shen, Yang
Zhou, Qingbo
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Thrombin plays a pivotal role in the pathogenesis of atherosclerosis.
Baicalin, an active flavonoid compound, was shown to attenuate the development of atherosclerosis, but the mechanism remains elusive.
In the present study, the role and mechanism of baicalin in thrombin-induced cell injury was investigated in human umbilical vein endothelial cells (HUVECs).
Our results showed that baicalin significantly reduced thrombin-induced apoptosis of HUVECs.
Additional experiments showed that baicalin inhibited thrombin-induced NF-κB activation and PAR-1 expression.
In addition, baicalin decreased thrombin-induced PAR-1 expression by inhibiting ERK pathway.
These results indicated that baicalin has protective effects on thrombin-induced cell injury in HUVECs possibly through inhibition of PAR-1 expression and its downstream NF-κB activation, which was mediated by ERK1/2 activation.
American Psychological Association (APA)
Zhang, Anna& Hou, Yunfeng& Sun, Chao& Pu, Ying& Sun, Yu& Zhang, Yuan…[et al.]. 2019. Baicalin Protects against Thrombin-Induced Cell Injury in Human Umbilical Vein Endothelial Cells. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123750
Modern Language Association (MLA)
Zhang, Anna…[et al.]. Baicalin Protects against Thrombin-Induced Cell Injury in Human Umbilical Vein Endothelial Cells. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1123750
American Medical Association (AMA)
Zhang, Anna& Hou, Yunfeng& Sun, Chao& Pu, Ying& Sun, Yu& Zhang, Yuan…[et al.]. Baicalin Protects against Thrombin-Induced Cell Injury in Human Umbilical Vein Endothelial Cells. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123750
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123750