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Systematic Review with Meta-Analysis: Efficacy and Safety of Direct-Acting Antivirals for Chronic Hepatitis C Genotypes 5 and 6
Joint Authors
Thakkinstian, Ammarin
Sobhonslidsuk, Abhasnee
Chaikledkaew, Usa
Due, Ong The
Genuino, Anne Julienne M.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Direct-acting antivirals (DAAs) are modern treatments for chronic hepatitis C infection, but majority of available evidence on its treatment effect covers genotypes 1 to 4.
Therefore, the efficacy and safety of DAAs for genotypes 5 and 6 need to be analysed.
Studies were identified from Medline, Scopus, and CENTRAL and a Chinese database CNKI, from inception until Dec 4, 2018.
Clinical trials were included if they enrolled patients with genotypes 5 and/or 6 infection, any type of second-generation DAAs was studied, and sustained virological response was assessed at the 12th week after treatment (SVR12) as outcome measure.
Meta-analysis using metaprop statistical program was applied for pooling proportions if data were sufficient (i.e., at least 2 studies).
Thirteen studies were included in the analysis.
Four studies assessed the efficacy of four DAA regimens in genotype 5 patients, which were mainly sofosbuvir (SOF) plus pegylated-interferon/ribavirin (PR) or other DAAs, with SVR12 ranging from 94.4% to 100%.
Twelve studies assessed the efficacy of seven DAA regimens among genotype 6 patients, but only two DAA regimens (i.e., SOF + PR and SOF/ledipasvir) had sufficient data for pooling.
The pooled SVR12 rates (95% CI) were 99.6% (92.2 to 100) for SOF + PR and 99.2% (96.5 to 100) for SOF/ledipasvir.
No treatment-related serious adverse event was reported, while the nonserious adverse events were comparable to other genotypes.
In conclusion, DAAs are effective and may be safe for the treatment of chronic hepatitis C genotypes 5 and 6.
However, our evidence is based on noncomparative studies; hence, further larger-scale randomized controlled trials in these genotypes are still required.
American Psychological Association (APA)
Due, Ong The& Chaikledkaew, Usa& Genuino, Anne Julienne M.& Sobhonslidsuk, Abhasnee& Thakkinstian, Ammarin. 2019. Systematic Review with Meta-Analysis: Efficacy and Safety of Direct-Acting Antivirals for Chronic Hepatitis C Genotypes 5 and 6. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1123763
Modern Language Association (MLA)
Due, Ong The…[et al.]. Systematic Review with Meta-Analysis: Efficacy and Safety of Direct-Acting Antivirals for Chronic Hepatitis C Genotypes 5 and 6. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1123763
American Medical Association (AMA)
Due, Ong The& Chaikledkaew, Usa& Genuino, Anne Julienne M.& Sobhonslidsuk, Abhasnee& Thakkinstian, Ammarin. Systematic Review with Meta-Analysis: Efficacy and Safety of Direct-Acting Antivirals for Chronic Hepatitis C Genotypes 5 and 6. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1123763
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123763