Vitamin E Loaded Naringenin Nanoemulsion via Intranasal Delivery for the Management of Oxidative Stress in a 6-OHDA Parkinson’s Disease Model
Joint Authors
Gaba, Bharti
Khan, Tahira
Haider, Md Faheem
Alam, Tausif
Baboota, Sanjula
Parvez, Suhel
Ali, Javed
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-14
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Purpose.
The present study is an attempt to develop a vitamin E loaded naringenin (NRG) Nanoemulsion (NE) for direct nose-to-brain delivery for better management of Parkinson's disease (PD).
Methods.
The optimized NE was evaluated for efficacy in PD using multiple behavioral studies (including narrow beam test, muscular coordination test, grip strength test, forced swimming test, and akinesia test) in a rat model.
Optimized formulation was evaluated for droplet size, polydispersity index (PDI), refractive index, transmittance, zeta potential, and viscosity.
Results.
Optimized NE had a droplet size of 38.70 ± 3.11nm, PDI of 0.14 ± 0.0024, refractive index of 1.43 ± 0.01, transmittance of 98.12 ± 0.07 %, zeta potential of − 27.4 ± 0.14 mV, and viscosity of 19.67 ± 0.25 Pa s.
Behavioral studies showed that 6-OHDA induced PD in rats were successfully reversed when administered with NRG NE intranasally along with the levodopa.
While the levels of GSH and SOD were significantly higher, levels of MDA were significantly lower in the group treated with NRG NE via intranasal route along with levodopa.
Conclusion.
Encouraging results from current study provide evidence for possible efficacy of a novel noninvasive intranasal delivery system of NRG for management of PD related symptoms.
American Psychological Association (APA)
Gaba, Bharti& Khan, Tahira& Haider, Md Faheem& Alam, Tausif& Baboota, Sanjula& Parvez, Suhel…[et al.]. 2019. Vitamin E Loaded Naringenin Nanoemulsion via Intranasal Delivery for the Management of Oxidative Stress in a 6-OHDA Parkinson’s Disease Model. BioMed Research International،Vol. 2019, no. 2019, pp.1-20.
https://search.emarefa.net/detail/BIM-1123798
Modern Language Association (MLA)
Gaba, Bharti…[et al.]. Vitamin E Loaded Naringenin Nanoemulsion via Intranasal Delivery for the Management of Oxidative Stress in a 6-OHDA Parkinson’s Disease Model. BioMed Research International No. 2019 (2019), pp.1-20.
https://search.emarefa.net/detail/BIM-1123798
American Medical Association (AMA)
Gaba, Bharti& Khan, Tahira& Haider, Md Faheem& Alam, Tausif& Baboota, Sanjula& Parvez, Suhel…[et al.]. Vitamin E Loaded Naringenin Nanoemulsion via Intranasal Delivery for the Management of Oxidative Stress in a 6-OHDA Parkinson’s Disease Model. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-20.
https://search.emarefa.net/detail/BIM-1123798
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123798