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Combination of Sodium Selenite and Doxorubicin Prodrug Ac-Phe-Lys-PABC-ADM Affects Gastric Cancer Cell Apoptosis in Xenografted Mice
Joint Authors
Zhang, Zixiong
Huang, Chuying
Sun, Jianhua
Wu, Bo
Ge, Jian
Li, Xiaodan
Tan, Zifu
Fang, Xiaojun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The incidence of gastric cancer is extremely high in China, prompting the development of effective therapeutic strategies.
Sodium selenite (SS) affects the proliferation and redifferentiation of gastric cancer cells and the Adriamycin prodrug Ac-Phe-Lys-PABC-ADM (PADM) reduces toxicity in gastric cancer treatment.
However, the mechanisms involved therein remain unclear.
In this study, nude mice were transplanted with SGC-7901 gastric cancer cells to construct a tumor xenograft model.
After administration of SS and PADM, tumor weight and size were reduced.
In addition, the levels of alanine aminotransferase, aspartate transaminase, creatinine, and lactate dehydrogenase were decreased, indicating improved hepatic and renal function and inhibited cancer cell metabolism.
Furthermore, combined treatment of SS and PADM downregulated the expression of cell cycle-related proteins (cyclin-dependent kinase 4, Ki67, cyclin E, and cyclin D1), elevated that of proapoptosis proteins (Bax, cleaved caspase-3, cleaved caspase-9, and P53), and upregulated that of mitochondrial apoptosis-associated proteins (apoptotic protease activating factor 1 and second mitochondria-derived activator of caspases).
In conclusion, combined treatment of SS and PADM effectively promoted apoptosis in gastric cancer xenografts via the mitochondrial apoptosis pathway.
American Psychological Association (APA)
Wu, Bo& Ge, Jian& Zhang, Zixiong& Huang, Chuying& Li, Xiaodan& Tan, Zifu…[et al.]. 2019. Combination of Sodium Selenite and Doxorubicin Prodrug Ac-Phe-Lys-PABC-ADM Affects Gastric Cancer Cell Apoptosis in Xenografted Mice. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123859
Modern Language Association (MLA)
Wu, Bo…[et al.]. Combination of Sodium Selenite and Doxorubicin Prodrug Ac-Phe-Lys-PABC-ADM Affects Gastric Cancer Cell Apoptosis in Xenografted Mice. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1123859
American Medical Association (AMA)
Wu, Bo& Ge, Jian& Zhang, Zixiong& Huang, Chuying& Li, Xiaodan& Tan, Zifu…[et al.]. Combination of Sodium Selenite and Doxorubicin Prodrug Ac-Phe-Lys-PABC-ADM Affects Gastric Cancer Cell Apoptosis in Xenografted Mice. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123859