Pathogenic Effects and Potential Regulatory Mechanisms of Tea Polyphenols on Obesity
Joint Authors
Li, Zhandong
Liu, Yue
Zhao, Weihao
Wu, Xiuhua
Jiang, Xiujuan
Yang, Lili
Xing, Chaoqun
You, Lixin
Song, Jiwei
Li, Hao
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Overweight and obesity are major threats to human health.
Tea polyphenols exert multiple beneficial effects on human health and may play a positive regulatory role in fat assumption.
However, how tea polyphenols contribute to the regulation of fat metabolism remains unclear to date.
Small RNA expression profile can be regulated by tea polyphenols in adipocytes.
Therefore, tea polyphenols may regulate fat metabolism by controlling small RNA-associated biological processes.
In this study, we developed a systematic research platform based on mouse models and performed small RNA sequencing to identify the specific role of small RNAs in the regulatory effect of tea polyphenols on fat metabolism.
We compared the expression levels of different small RNA subtypes, including piRNAs and miRNAs, and identified a group of differentially expressed small RNAs in the experimental and control groups.
Most of these small RNAs participate in lipid metabolism, suggesting that small RNAs play a significant role in tea polyphenol-associated obesity and related pathogenesis.
Furthermore, gene ontology and KEGG pathway enrichment indicated that small RNAs influence the regulatory effects of tea polyphenols on obesity, revealing the potential pathogenic mechanisms for such nutritional disease.
American Psychological Association (APA)
Li, Zhandong& Liu, Yue& Zhao, Weihao& Wu, Xiuhua& Jiang, Xiujuan& Yang, Lili…[et al.]. 2019. Pathogenic Effects and Potential Regulatory Mechanisms of Tea Polyphenols on Obesity. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1123923
Modern Language Association (MLA)
Li, Zhandong…[et al.]. Pathogenic Effects and Potential Regulatory Mechanisms of Tea Polyphenols on Obesity. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1123923
American Medical Association (AMA)
Li, Zhandong& Liu, Yue& Zhao, Weihao& Wu, Xiuhua& Jiang, Xiujuan& Yang, Lili…[et al.]. Pathogenic Effects and Potential Regulatory Mechanisms of Tea Polyphenols on Obesity. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1123923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123923