Polycystin-1 Inhibits Cell Proliferation through Phosphatase PP2AB56α
Joint Authors
Tang, Yan
Yang, JungWoo
Zheng, Wang
Tang, Jingfeng
Chen, Xing-Zhen
Yang, Jianzheng
Wang, Zuocheng
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Autosomal dominant polycystic kidney disease (ADPKD) is associated with a number of cellular defects such as hyperproliferation, apoptosis, and dedifferentiation.
Mutations in polycystin-1 (PC1) account for ∼85% of ADPKD.
Here, we showed that wild-type (WT) or mutant PC1 composed of the last five transmembrane (TM) domains and the C-terminus (termed PC1-5TMC) inhibits cell proliferation and protein translation, as well as the downstream effectors of mTOR, consistent with previous reports.
Knockdown of B56α, a subunit of the protein phosphatase 2A (PP2A) complex, or application of PP2A inhibitor okadaic acid or calyculin A, abolished the inhibitory effect of PC1 and PC1-5TMC on proliferation, indicating that PP2A/B56α mediates the regulation of cell proliferation by PC1.
In addition to the phosphorylated S6 and 4EBP1, B56α was also downregulated by PC1 and PC1-5TMC.
Furthermore, the downregulation of B56α, which may be mediated by mTOR but not AKT, can account for the dependence of PC1-inhibited proliferation on PP2A.
American Psychological Association (APA)
Tang, Yan& Yang, JungWoo& Zheng, Wang& Tang, Jingfeng& Chen, Xing-Zhen& Yang, Jianzheng…[et al.]. 2019. Polycystin-1 Inhibits Cell Proliferation through Phosphatase PP2AB56α. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123927
Modern Language Association (MLA)
Tang, Yan…[et al.]. Polycystin-1 Inhibits Cell Proliferation through Phosphatase PP2AB56α. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1123927
American Medical Association (AMA)
Tang, Yan& Yang, JungWoo& Zheng, Wang& Tang, Jingfeng& Chen, Xing-Zhen& Yang, Jianzheng…[et al.]. Polycystin-1 Inhibits Cell Proliferation through Phosphatase PP2AB56α. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123927
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123927