The Additional Effect of Autologous Platelet Concentrates to Coronally Advanced Flap in the Treatment of Gingival Recessions: A Systematic Review and Meta-Analysis
Joint Authors
Li, Rong
Liu, Yanqing
Xu, Tong
Zhao, Haijiao
Hou, Jingya
Wu, Yun
Zhang, Dongmei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-25
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background.
To improve the efficacy of regenerative treatment for gingival recessions, the autologous platelet concentrates (APCs) combined with coronally advanced flap (CAF) have been investigated.
However, few studies systematically assess the complementary effect of APCs in periodontal regeneration.
The present study aims to evaluate the additional effect of different types of APCs to CAF in the treatment of gingival recessions.
Methods.
Electronic databases (EMBASE, MEDLINE, and Cochrane Central Register of Controlled Trails) and relevant journals were searched until May 15, 2019.
Only randomized controlled trials (RCTs) in English were included.
Outcome variables include root coverage (RC), recession depth (RD), clinical attachment level (CAL), keratinized tissue width (KTW), and gingival thickness (GT).
Data were analyzed with Revman5.3.
The estimate of effect sizes was expressed as the mean differences and the 95% confidence interval.
Results.
8 RCTs involving 170 patients (328 sites) were included.
Our meta-analysis indicated RC, RD, CAL, KTW, and GT were better improved in the CAF plus APCs groups than the CAF alone.
The subgroup analyses revealed that platelet-rich fibrin (PRF) brought significant improvement in RC, RD, CAL, and GT.
Concentrated growth factors (CGF) lead clinic beneficial in CAL, KTW, and GT.
No significant effect of platelet-rich plasma (PRP) could be found in any clinical parameters when combined with CAF.
Conclusions.
PRF could exert additional effect to CAF; the preferred treatment for gingival recessions was considered.
Based on the limited studies, it seemed that PRP failed to show any additional effect and it was not suggested for gingival recessions.
Given the limited research and high risk of bias, it is still needed to confirm the additional effect of CGF by more high-quality studies.
American Psychological Association (APA)
Li, Rong& Liu, Yanqing& Xu, Tong& Zhao, Haijiao& Hou, Jingya& Wu, Yun…[et al.]. 2019. The Additional Effect of Autologous Platelet Concentrates to Coronally Advanced Flap in the Treatment of Gingival Recessions: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1123943
Modern Language Association (MLA)
Li, Rong…[et al.]. The Additional Effect of Autologous Platelet Concentrates to Coronally Advanced Flap in the Treatment of Gingival Recessions: A Systematic Review and Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1123943
American Medical Association (AMA)
Li, Rong& Liu, Yanqing& Xu, Tong& Zhao, Haijiao& Hou, Jingya& Wu, Yun…[et al.]. The Additional Effect of Autologous Platelet Concentrates to Coronally Advanced Flap in the Treatment of Gingival Recessions: A Systematic Review and Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1123943
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123943