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A Meta-Analysis on the Seroprevalence of Parvovirus B19 among Patients with Sickle Cell Disease
Joint Authors
Obeid Mohamed, Sagad Omer
Osman Mohamed, Esraa Mohamed
Ahmed Osman, Afnan Abugundul
Abdellatif MohamedElmugadam, Fatima Abdelhakam
Abdalla Ibrahim, Gehad Abdelmonem
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Parvovirus B19 (B19 V) infection had been reported to be more frequent with serious clinical outcomes in patients with sickle cell disease (SCD) than in the general population.
There is a wide variation in data among the existing literature regarding the seroprevalence of B19 V in patients with SCD.
These data require further summary and analyses for better accuracy.
This systematic review and meta-analysis was done to estimate the seroprevalence of B19 V in patients with SCD.
Methods.
This study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
The databases of MEDLINE/PubMed, Virtual Health Library (VHL), ScienceDirect, Google Scholar, and OpenGrey were used for the systematic search.
The random-effects model was used to estimate the pooled prevalence with the corresponding 95% confidence interval (CI) using OpenMeta Analyst software.
Publication bias was estimated based on Begg’s test, Egger’s test, and examination of the funnel plot.
Subgroup analyses and metaregression were used to explore the moderators of heterogeneity between studies.
Results.
A total of 18 studies including 2890 patients were analyzed.
The overall IgG seroprevalence of B19 V infection among patients with SCD was found to be 48.8% (95% CI 39.5%–58.0%).
Evidence of publication bias was not detected.
Evidence of acute viral infection detected by positive IgM antibodies among the screened SCD patients was found in 8.30% (95% CI 5.20%–11.4%) of them.
There was a statistically significant association between seroprevalence of B19 V and geographical areas.
Conclusion.
There was a high prevalence of B19 V in patients with SCD.
Healthcare providers need to be aware of the magnitude of B19 V infection in patients with SCD to ensure effective management.
This review could provide a comprehensive view of B19 V prevalence in this susceptible population.
American Psychological Association (APA)
Obeid Mohamed, Sagad Omer& Osman Mohamed, Esraa Mohamed& Ahmed Osman, Afnan Abugundul& Abdellatif MohamedElmugadam, Fatima Abdelhakam& Abdalla Ibrahim, Gehad Abdelmonem. 2019. A Meta-Analysis on the Seroprevalence of Parvovirus B19 among Patients with Sickle Cell Disease. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1124077
Modern Language Association (MLA)
Obeid Mohamed, Sagad Omer…[et al.]. A Meta-Analysis on the Seroprevalence of Parvovirus B19 among Patients with Sickle Cell Disease. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1124077
American Medical Association (AMA)
Obeid Mohamed, Sagad Omer& Osman Mohamed, Esraa Mohamed& Ahmed Osman, Afnan Abugundul& Abdellatif MohamedElmugadam, Fatima Abdelhakam& Abdalla Ibrahim, Gehad Abdelmonem. A Meta-Analysis on the Seroprevalence of Parvovirus B19 among Patients with Sickle Cell Disease. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1124077
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124077