Measuring Similarity among Protein Sequences Using a New Descriptor
Joint Authors
Abo-Elkhier, Mervat M.
Abd Elwahaab, Marwa A.
Abo El Maaty, Moheb I.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The comparison of protein sequences according to similarity is a fundamental aspect of today’s biomedical research.
With the developments of sequencing technologies, a large number of protein sequences increase exponentially in the public databases.
Famous sequences’ comparison methods are alignment based.
They generally give excellent results when the sequences under study are closely related and they are time consuming.
Herein, a new alignment-free method is introduced.
Our technique depends on a new graphical representation and descriptor.
The graphical representation of protein sequence is a simple way to visualize protein sequences.
The descriptor compresses the primary sequence into a single vector composed of only two values.
Our approach gives good results with both short and long sequences within a little computation time.
It is applied on nine beta globin, nine ND5 (NADH dehydrogenase subunit 5), and 24 spike protein sequences.
Correlation and significance analyses are also introduced to compare our similarity/dissimilarity results with others’ approaches, results, and sequence homology.
American Psychological Association (APA)
Abo-Elkhier, Mervat M.& Abd Elwahaab, Marwa A.& Abo El Maaty, Moheb I.. 2019. Measuring Similarity among Protein Sequences Using a New Descriptor. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1124094
Modern Language Association (MLA)
Abo-Elkhier, Mervat M.…[et al.]. Measuring Similarity among Protein Sequences Using a New Descriptor. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1124094
American Medical Association (AMA)
Abo-Elkhier, Mervat M.& Abd Elwahaab, Marwa A.& Abo El Maaty, Moheb I.. Measuring Similarity among Protein Sequences Using a New Descriptor. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1124094
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124094