Nephrotoxicity Evaluation on Cisplatin Combined with 5-HT3 Receptor Antagonists: A Retrospective Study
Joint Authors
Kou, Wen
Qin, Hongyan
Hanif, Shahbaz
Wu, Xinan
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
5-HT3 receptor antagonist (ondansetron) has been reported to have nephrotoxic effect when combined with cisplatin in mice; however, little evidence exists in explaining its nephrotoxic effects on patients.
The aim of this present study was to investigate whether 5-HT3 receptor antagonist could enhance or aggravate the incidence of cisplatin-induced nephrotoxicity in patients.
Methods.
We retrospectively reviewed 600 tumor patients which were treated with cisplatin (⩾60 mg/m2) as a first-time chemotherapy and combined with 5-HT3 receptor antagonist (i.e., ondansetron, tropisetron, or ramosetron, each kind of 5-HT3 receptor antagonist contains 200 cases) between January 2010 and December 2015.
Cisplatin dosing, the baseline creatinine clearance, and other independent risk factors such as patient’s age, sex, PS score, and weight associated with nephrotoxicity were evaluated in a multivariable model.
Results.
The incidence of Grade ⩾ 2 serum creatinine elevation in cisplatin + ondansetron group was significantly higher than cisplatin + tropisetron group (P=0.04), but no significant difference was found between cisplatin + ondansetron group and cisplatin + ramosetron group (P=0.3).
It was also found that cisplatin dosage and tumor type were independent risk factors in the development of nephrotoxicity.
Conclusion.
Higher cisplatin dosage and regular use of ondansetron combined with cisplatin are more likely to increase the incidence of nephrotoxicity; tropisetron showed the relatively mild effect on kidney function, suggesting that tropisetron is a preferable alternative in the process of cisplatin chemotherapy.
American Psychological Association (APA)
Kou, Wen& Qin, Hongyan& Hanif, Shahbaz& Wu, Xinan. 2018. Nephrotoxicity Evaluation on Cisplatin Combined with 5-HT3 Receptor Antagonists: A Retrospective Study. BioMed Research International،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1124096
Modern Language Association (MLA)
Kou, Wen…[et al.]. Nephrotoxicity Evaluation on Cisplatin Combined with 5-HT3 Receptor Antagonists: A Retrospective Study. BioMed Research International No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1124096
American Medical Association (AMA)
Kou, Wen& Qin, Hongyan& Hanif, Shahbaz& Wu, Xinan. Nephrotoxicity Evaluation on Cisplatin Combined with 5-HT3 Receptor Antagonists: A Retrospective Study. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1124096
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124096