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Overexpression of ICAM-1 Predicts Poor Survival in High-Grade Serous Ovarian Carcinoma: A Study Based on TCGA and GEO Databases and Tissue Microarray
Joint Authors
Li, Feng
Ding, Yu-Song
Wang, Shasha
Yin, Can
Zhang, Ying
Zhang, Lu
Tao, Lin
Liang, Weihua
Pang, Lijuan
Fu, Ruiting
Jia, Wei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Intercellular cell adhesion molecule-1 (ICAM-1), an important adhesion molecule in the immunoglobulin superfamily, is expressed on many cell types.
Recent studies have identified ICAM-1 as a potential oncogene that promotes the development of epithelial ovarian cancer (EOC); it was also found to be associated with poor survival.
However, the clinical significance of its expression in high-grade serous ovarian carcinoma (HGSOC) is unclear.
Thus, this study aimed to investigate the significance of ICAM-1 expression in HGSOC.
Data on ICAM1 expression and mutations in serous ovarian carcinoma (SOC) were obtained from the Cancer Genome Atlas (TCGA), and ICAM1 mRNA expression data in HGSOC were obtained from the Gene Expression Omnibus (GEO) database.
ICAM-1 expression was evaluated by immunohistochemistry in HGSOC and normal fallopian tube tissues microarray.
In TCGA data, amplification/mutation of ICAM1 was identified in 12% of serous ovarian carcinoma samples, and overexpression of ICAM1 mRNA predicted reduced overall survival in SOC.
From TCGA and GEO data, SOC patients with ICAM1 mRNA overexpression treated with chemotherapeutic drugs that contained taxol or taxol and platin together had significantly reduced progression-free survival.
According to GEO data, ICAM1 mRNA expression was found significantly higher in HGSOC than in control samples.
In our study, ICAM-1 overexpression was observed in 63.1% (65/103) of HGSOCs.
As a prognostic biomarker, overexpression of ICAM-1 predicted reduced recurrence-free and overall survival and is an independent risk factor for poor prognosis.
These findings suggest that overexpression of ICAM-I is an independent indicator of poor prognosis for HGSOC and that it can serve as an effective clinical prognostic biomarker for this disease.
American Psychological Association (APA)
Wang, Shasha& Yin, Can& Zhang, Ying& Zhang, Lu& Tao, Lin& Liang, Weihua…[et al.]. 2019. Overexpression of ICAM-1 Predicts Poor Survival in High-Grade Serous Ovarian Carcinoma: A Study Based on TCGA and GEO Databases and Tissue Microarray. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1124134
Modern Language Association (MLA)
Wang, Shasha…[et al.]. Overexpression of ICAM-1 Predicts Poor Survival in High-Grade Serous Ovarian Carcinoma: A Study Based on TCGA and GEO Databases and Tissue Microarray. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1124134
American Medical Association (AMA)
Wang, Shasha& Yin, Can& Zhang, Ying& Zhang, Lu& Tao, Lin& Liang, Weihua…[et al.]. Overexpression of ICAM-1 Predicts Poor Survival in High-Grade Serous Ovarian Carcinoma: A Study Based on TCGA and GEO Databases and Tissue Microarray. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1124134
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124134