Retinoblastoma Binding Protein 5 Correlates with the Progression in Hepatocellular Carcinoma
Joint Authors
Huang, Junxing
Yu, Hong
Zhou, Huiling
Bao, Jingjing
Zhu, Xiaowei
Dai, Guihong
Jiang, Xiaoqin
Jiao, Xia
Sheng, Haihui
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) is one of the most common malignancy tumors with insidious onset, rapid development and metastasis, and poor prognosis.
Therefore, it is necessary to understand molecular mechanisms of HCC and identify clinically useful biomarkers for it.
This study aimed to investigate the role of retinoblastoma binding protein 5 (RBBP5) in HCC.
The expression level of RBBP5 was examined by immunohistochemistry and western blot.
The effect of RBBP5 on cell cycle, proliferation, apoptosis, and drug sensitivity was analyzed.
RBBP5 was significantly upregulated in HCC tissues and cells.
High RBBP5 expression was significantly associated with elevated level of AFP, advanced TNM stage, high Ki-67 expression, larger tumor size, and poor prognosis.
Knockdown of RBBP5 significantly inhibited proliferation of HCC cells through cell cycle arrest.
In addition, inhibition of RBBP5 increased the sensitivity of HCC cells to doxorubicin.
In conclusion, our findings suggest that RBBP5 plays an important role in the progression of HCC and may serve as a novel biomarker and potential therapeutic target for HCC.
American Psychological Association (APA)
Zhou, Huiling& Bao, Jingjing& Zhu, Xiaowei& Dai, Guihong& Jiang, Xiaoqin& Jiao, Xia…[et al.]. 2018. Retinoblastoma Binding Protein 5 Correlates with the Progression in Hepatocellular Carcinoma. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1124142
Modern Language Association (MLA)
Zhou, Huiling…[et al.]. Retinoblastoma Binding Protein 5 Correlates with the Progression in Hepatocellular Carcinoma. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1124142
American Medical Association (AMA)
Zhou, Huiling& Bao, Jingjing& Zhu, Xiaowei& Dai, Guihong& Jiang, Xiaoqin& Jiao, Xia…[et al.]. Retinoblastoma Binding Protein 5 Correlates with the Progression in Hepatocellular Carcinoma. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1124142
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124142