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Selected Enzyme Inhibitory Effects of Euphorbia characias Extracts
Joint Authors
Era, Benedetta
Medda, Rosaria
Montoro, Paola
Tuberoso, Carlo Ignazio Giovanni
Di Petrillo, Amalia
Floris, Sonia
Piano, Dario
Fais, Antonella
Pintus, Francesca
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Extracts of aerial part of Euphorbia characias were examined to check potential inhibitors for three selected enzymes involved in several metabolic disorders.
Water and ethanol extracts from leaves and flowers showed in vitro inhibitory activity toward α-amylase, α-glucosidase, and xanthine oxidase.
IC50 values were calculated for all the extracts and the ethanolic extracts were found to exert the best effect.
In particular, for the α-glucosidase activity, the extracts resulted to be 100-fold more active than the standard inhibitor.
The inhibition mode was investigated by Lineweaver-Burk plot analysis.
E.
characias extracts display different inhibition behaviors toward the three enzymes acting as uncompetitive, noncompetitive, and mixed-type inhibitors.
Moreover, ethanolic extracts of E.
characias showed no cytotoxic activity and exhibited antioxidant capacity in a cellular model.
The LC-DAD metabolic profile was also performed and it showed that leaves and flowers extracts contain high levels of quercetin derivatives.
The results suggest that E.
characias could be a promising source of natural inhibitors of the enzymes involved in carbohydrate uptake disorders and oxidative stress.
American Psychological Association (APA)
Fais, Antonella& Era, Benedetta& Di Petrillo, Amalia& Floris, Sonia& Piano, Dario& Montoro, Paola…[et al.]. 2018. Selected Enzyme Inhibitory Effects of Euphorbia characias Extracts. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1124169
Modern Language Association (MLA)
Fais, Antonella…[et al.]. Selected Enzyme Inhibitory Effects of Euphorbia characias Extracts. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1124169
American Medical Association (AMA)
Fais, Antonella& Era, Benedetta& Di Petrillo, Amalia& Floris, Sonia& Piano, Dario& Montoro, Paola…[et al.]. Selected Enzyme Inhibitory Effects of Euphorbia characias Extracts. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1124169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124169