Functional Polymorphisms in IRAKs Are Related to Hepatocellular Carcinoma Risk in Chinese Population
Joint Authors
Hu, Zhibin
Dai, Juncheng
Wang, Hui
Song, Ci
Qi, Qi
Huang, Tongtong
Wang, Lijuan
Chen, Jianguo
Zhu, Jian
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Interleukin 1 receptor associated kinases (IRAKs) play a central role in TLR signaling pathway.
Scarce literature has investigated the association of potential functional genetic variants of IRAKs with Hepatitis B Virus- (HBV-) related hepatocellular carcinoma (HCC).
Methods.
A case-control study with 1,538 HBV-positive HCC patients and 1,465 chronic HBV carriers was conducted to evaluate the effects of common missense variants of IRAK family members on HCC.
Proliferation assays and real-time polymerase chain reactions were carried out to evaluate the functions.
Multivariable adjusted logistic regression was adopted to estimate effect size and identify risk factors.
Results.
Association analysis indicated that rs4251545 A allele of IRAK4 (p.Ala428Thr) was positively associated with HBV-related HCC risk (OR = 1.30, 95% CI: 1.09–1.54, P=0.003).
Functional annotation indicated that rs4251545 reduced its own expression in liver (P=0.031).
Further molecular functional analysis detected that rs4251545 increased the proliferation rate of L02 cells (P<0.05).
Meanwhile, rs4251545 reduced mRNA expressions of IL-6, IL-8, CXCL-1, and CXCL-2 in L02 cells (P<0.01).
Conclusion.
rs4251545 of IRAK4 (p.Ala428Thr) modified the susceptibility to HBV-related HCC via increased proliferation rate and reduced production of inflammatory cytokines and chemokines.
Further well-designed experiments are warranted to validate our findings.
American Psychological Association (APA)
Wang, Hui& Song, Ci& Qi, Qi& Huang, Tongtong& Wang, Lijuan& Chen, Jianguo…[et al.]. 2018. Functional Polymorphisms in IRAKs Are Related to Hepatocellular Carcinoma Risk in Chinese Population. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1124189
Modern Language Association (MLA)
Wang, Hui…[et al.]. Functional Polymorphisms in IRAKs Are Related to Hepatocellular Carcinoma Risk in Chinese Population. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1124189
American Medical Association (AMA)
Wang, Hui& Song, Ci& Qi, Qi& Huang, Tongtong& Wang, Lijuan& Chen, Jianguo…[et al.]. Functional Polymorphisms in IRAKs Are Related to Hepatocellular Carcinoma Risk in Chinese Population. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1124189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124189