![](/images/graphics-bg.png)
Mice Selected for Acute Inflammation Present Altered Immune Response during Pristane-Induced Arthritis Progression
Joint Authors
Cabrera, Wafa H. K.
Ribeiro, Orlando G.
Jensen, José Ricardo
Ibañez, Olga M.
Starobinas, Nancy
Correa, Mara A.
Borrego, Andrea
Barros, Michele
Katz, Iana S. S.
Canhamero, Tatiane
Spadafora-Ferreira, Monica
Fernandes, Jussara G.
De Franco, Marcelo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Mouse lines selected for maximal (AIRmax) or minimal acute inflammatory reaction (AIRmin) were used to characterize the immune response and the influence of genetic background during pristane-induced arthritis (PIA).
Susceptible AIRmax mice demonstrated exacerbated cellular profiles during PIA, with intense infiltration of lymphocytes, as well as monocytes/macrophages and neutrophils, producing higher levels of IL-1β, IFN-γ, TNF-α, IL-10, total IgG3, and chemokines.
Resistant AIRmin mice controlled cell activation more efficiently than the AIRmax during arthritis progression.
The weight alterations of the spleen and thymus in the course of PIA were observed.
Our data suggest that selected AIRmax cellular and genetic immune mechanisms contribute to cartilage damage and arthritis severity, evidencing many targets for therapeutic actions.
American Psychological Association (APA)
Correa, Mara A.& Borrego, Andrea& Jensen, José Ricardo& Cabrera, Wafa H. K.& Barros, Michele& Katz, Iana S. S.…[et al.]. 2018. Mice Selected for Acute Inflammation Present Altered Immune Response during Pristane-Induced Arthritis Progression. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1124202
Modern Language Association (MLA)
Correa, Mara A.…[et al.]. Mice Selected for Acute Inflammation Present Altered Immune Response during Pristane-Induced Arthritis Progression. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1124202
American Medical Association (AMA)
Correa, Mara A.& Borrego, Andrea& Jensen, José Ricardo& Cabrera, Wafa H. K.& Barros, Michele& Katz, Iana S. S.…[et al.]. Mice Selected for Acute Inflammation Present Altered Immune Response during Pristane-Induced Arthritis Progression. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1124202
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124202