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Stress Response and Virulence Potential Modulating Effect of Peppermint Essential Oil in Campylobacter jejuni
Joint Authors
Abraham, H.
Horvath, Gyorgyi
Kovács, Tamás
Márk, László
Kovács, J. K.
Felső, P.
Schmidt, J.
Dorn, Á.
Cox, A.
Emődy, L.
Schneider, György
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Campylobacter jejuni is one of the most common food-borne bacteria that causes gastrointestinal symptoms.
In the present study we have investigated the molecular basis of the anti-Campylobacter effect of peppermint essential oil (PEO), one of the oldest EO used to treat gastrointestinal diseases.
Transcriptomic, quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and proteomic, two-dimensional polyacryl amid gel electrophoresis (2D-PAGE) methods have revealed that, in the presence of a sublethal concentration of PEO, the expression of several virulence-associated genes was decreased (cheY 0.84x; flhB 0.79x; flgE 0.205x; cadF 0.08x; wlaB 0.89x; porA 0.25x; cbf2 4.3x) while impaired motility was revealed with a functional analysis.
Scanning electron micrographs of the exposed cells showed that, unlike in the presence of other stresses, the originally curved C.
jejuni cells straightened upon PEO exposure.
Gaining insight into the molecular background of this stress response, we have revealed that in the presence of PEO C.
jejuni dominantly exerts a general stress response that elevates the expression of general stress genes like dnaK, groEL, groES (10.41x, 3.63x, and 4.77x).
The most important genes dps, sodB, and katA involved in oxidative stress responses showed however moderate transcriptional elevations (1,58x, 1,55x, and 1,85x).
American Psychological Association (APA)
Kovács, J. K.& Felső, P.& Horvath, Gyorgyi& Schmidt, J.& Dorn, Á.& Abraham, H.…[et al.]. 2019. Stress Response and Virulence Potential Modulating Effect of Peppermint Essential Oil in Campylobacter jejuni. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1124238
Modern Language Association (MLA)
Kovács, J. K.…[et al.]. Stress Response and Virulence Potential Modulating Effect of Peppermint Essential Oil in Campylobacter jejuni. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1124238
American Medical Association (AMA)
Kovács, J. K.& Felső, P.& Horvath, Gyorgyi& Schmidt, J.& Dorn, Á.& Abraham, H.…[et al.]. Stress Response and Virulence Potential Modulating Effect of Peppermint Essential Oil in Campylobacter jejuni. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1124238
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124238