Effects of Hexane Root Extract of Ferula hermonis Boiss. on Human Breast and Colon Cancer Cells: An In Vitro and In Vivo Study
Joint Authors
Wadaan, Mohammad A. M.
Alqahtani, Ali S.
Abutaha, Nael
Nasr, Fahd A.
Al-zharani, Mohammed
Noman, Omar M.
Mubarak, Mohammed
Abdelhabib, Semlali
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Breast and colon cancers are leading causes of cancer-related deaths globally.
Plants are a potential source of natural products that may be used for the treatment of cancer.
Ferula hermonis (FH) is reported to have diverse therapeutic effects.
However, there are few reports on the in vitro anticancer potential of FH extract.
Our results showed that the Ferula hermonis root hexane extract (FHRH) can induce dose-dependent cytotoxic effects in breast and colon cancer cells with MTT IC50 values of 18.2 and 25 μg/ml, respectively.
The FHRH extract induced apoptosis in both breast and colon cancer cells; this was confirmed by light and nuclear staining, q-PCR, and caspase 3/7 activation.
This study also demonstrated the antitumor activity of FHRH in 9,10-dimethylbenz[α]anthracene DMBA-induced rodent mammary tumor model.
The GC/MS analysis revealed the presence of 3,5-Dimethylbenzenemethanol, Alpha-Bisabolol, Alpha-pinene, Beta-pinene, and Baccatin III that have various pharmacological potentials.
Overall, the present study suggests that FHRH extract possesses anticancer potential which is mediated through apoptotic effects in MDA-MB-231 and LoVo cells.
The present study also considered a basis for further investigations into the potential use of FHRH extract as an anticancer therapy for breast and colon cancers.
American Psychological Association (APA)
Abutaha, Nael& Nasr, Fahd A.& Al-zharani, Mohammed& Alqahtani, Ali S.& Noman, Omar M.& Mubarak, Mohammed…[et al.]. 2019. Effects of Hexane Root Extract of Ferula hermonis Boiss. on Human Breast and Colon Cancer Cells: An In Vitro and In Vivo Study. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1124303
Modern Language Association (MLA)
Abutaha, Nael…[et al.]. Effects of Hexane Root Extract of Ferula hermonis Boiss. on Human Breast and Colon Cancer Cells: An In Vitro and In Vivo Study. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1124303
American Medical Association (AMA)
Abutaha, Nael& Nasr, Fahd A.& Al-zharani, Mohammed& Alqahtani, Ali S.& Noman, Omar M.& Mubarak, Mohammed…[et al.]. Effects of Hexane Root Extract of Ferula hermonis Boiss. on Human Breast and Colon Cancer Cells: An In Vitro and In Vivo Study. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1124303
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124303