Protein Kinase G Induces an Immune Response in Cows Exposed to Mycobacterium avium Subsp. paratuberculosis
Joint Authors
Richard-Greenblatt, Melissa
Bach, Eviatar
Chaffer, Marcelo
Lai, Wanika
Keefe, Greg
Begg, Douglas J.
Bach, Horacio
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
To establish infection, pathogens secrete virulence factors, such as protein kinases and phosphatases, to modulate the signal transduction pathways used by host cells to initiate immune response.
The protein MAP3893c is annotated in the genome sequence of Mycobacterium avium subspecies paratuberculosis (MAP), the causative agent of Johne’s disease, as the serine/threonine protein kinase G (PknG).
In this work, we report that PknG is a functional kinase that is secreted within macrophages at early stages of infection.
The antigen is able to induce an immune response from cattle exposed to MAP in the form of interferon gamma production after stimulation of whole blood with PknG.
These findings suggest that PknG may contribute to the pathogenesis of MAP by phosphorylating macrophage signalling and/or adaptor molecules as observed with other pathogenic mycobacterial species.
American Psychological Association (APA)
Bach, Horacio& Richard-Greenblatt, Melissa& Bach, Eviatar& Chaffer, Marcelo& Lai, Wanika& Keefe, Greg…[et al.]. 2018. Protein Kinase G Induces an Immune Response in Cows Exposed to Mycobacterium avium Subsp. paratuberculosis. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1124325
Modern Language Association (MLA)
Bach, Horacio…[et al.]. Protein Kinase G Induces an Immune Response in Cows Exposed to Mycobacterium avium Subsp. paratuberculosis. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1124325
American Medical Association (AMA)
Bach, Horacio& Richard-Greenblatt, Melissa& Bach, Eviatar& Chaffer, Marcelo& Lai, Wanika& Keefe, Greg…[et al.]. Protein Kinase G Induces an Immune Response in Cows Exposed to Mycobacterium avium Subsp. paratuberculosis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1124325
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124325