Comparative Analysis of V-Akt Murine Thymoma Viral Oncogene Homolog 3 (AKT3) Gene between Cow and Buffalo Reveals Substantial Differences for Mastitis
Joint Authors
Ullah, Farman
Bhattarai, Dinesh
Cheng, Zhangrui
Liang, Xianwei
Deng, Tingxian
Rehman, Zia Ur
Talpur, Hira Sajjad
Worku, Tesfaye
Brohi, Rahim Dad
Safdar, Muhammad
Ahmad, Muhammad Jamil
Salim, Mohammad
Khan, Momen
Ahmad, Hafiz Ishfaq
Zhang, Shujun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
AKT3 gene is a constituent of the serine/threonine protein kinase family and plays a crucial role in synthesis of milk fats and cholesterol by regulating activity of the sterol regulatory element binding protein (SREBP).
AKT3 is highly conserved in mammals and its expression levels during the lactation periods of cattle are markedly increased.
AKT3 is highly expressed in the intestine followed by mammary gland and it is also expressed in immune cells.
It is involved in the TLR pathways as effectively as proinflammatory cytokines.
The aims of this study were to investigate the sequences differences between buffalo and cow.
Our results showed that there were substantial differences between buffalo and cow in some exons and noteworthy differences of the gene size in different regions.
We also identified the important consensus sequence motifs, variation in 2000 upstream of ATG, substantial difference in the “3′UTR” region, and miRNA association in the buffalo sequences compared with the cow.
In addition, genetic analyses, such as gene structure, phylogenetic tree, position of different motifs, and functional domains, were performed to establish their correlation with other species.
This may indicate that a buffalo breed has potential resistance to disease, environment changes, and airborne microorganisms and some good production and reproductive traits.
American Psychological Association (APA)
Ullah, Farman& Bhattarai, Dinesh& Cheng, Zhangrui& Liang, Xianwei& Deng, Tingxian& Rehman, Zia Ur…[et al.]. 2018. Comparative Analysis of V-Akt Murine Thymoma Viral Oncogene Homolog 3 (AKT3) Gene between Cow and Buffalo Reveals Substantial Differences for Mastitis. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1124341
Modern Language Association (MLA)
Ullah, Farman…[et al.]. Comparative Analysis of V-Akt Murine Thymoma Viral Oncogene Homolog 3 (AKT3) Gene between Cow and Buffalo Reveals Substantial Differences for Mastitis. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1124341
American Medical Association (AMA)
Ullah, Farman& Bhattarai, Dinesh& Cheng, Zhangrui& Liang, Xianwei& Deng, Tingxian& Rehman, Zia Ur…[et al.]. Comparative Analysis of V-Akt Murine Thymoma Viral Oncogene Homolog 3 (AKT3) Gene between Cow and Buffalo Reveals Substantial Differences for Mastitis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1124341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124341