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Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer’s Disease
Joint Authors
Tandon, Ankit
Singh, Sangh Jyoti
Chaturvedi, Rajnish
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-30, 30 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-12
Country of Publication
Egypt
No. of Pages
30
Main Subjects
Abstract EN
Alzheimer’s disease (AD) and multiple sclerosis are major neurodegenerative diseases, which are characterized by the accumulation of abnormal pathogenic proteins due to oxidative stress, mitochondrial dysfunction, impaired autophagy, and pathogens, leading to neurodegeneration and behavioral deficits.
Herein, we reviewed the utility of plant polyphenols in regulating proliferation and differentiation of stem cells for inducing brain self-repair in AD and multiple sclerosis.
Firstly, we discussed the genetic, physiological, and environmental factors involved in the pathophysiology of both the disorders.
Next, we reviewed various stem cell therapies available and how they have proved useful in animal models of AD and multiple sclerosis.
Lastly, we discussed how polyphenols utilize the potential of stem cells, either complementing their therapeutic effects or stimulating endogenous and exogenous neurogenesis, against these diseases.
We suggest that polyphenols could be a potential candidate for stem cell therapy against neurodegenerative disorders.
American Psychological Association (APA)
Tandon, Ankit& Singh, Sangh Jyoti& Chaturvedi, Rajnish. 2018. Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer’s Disease. BioMed Research International،Vol. 2018, no. 2018, pp.1-30.
https://search.emarefa.net/detail/BIM-1124353
Modern Language Association (MLA)
Tandon, Ankit…[et al.]. Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer’s Disease. BioMed Research International No. 2018 (2018), pp.1-30.
https://search.emarefa.net/detail/BIM-1124353
American Medical Association (AMA)
Tandon, Ankit& Singh, Sangh Jyoti& Chaturvedi, Rajnish. Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer’s Disease. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-30.
https://search.emarefa.net/detail/BIM-1124353
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124353