Adhesion and Proliferation of Osteoblast-Like Cells on Porous Polyetherimide Scaffolds

Abstract EN

The purpose of this work was to investigate the porous polyetherimide scaffold (P-PEIs) as an alternative biopolymer for bone tissue engineering.

The P-PEIs was fabricated via solvent casting and particulate leaching technique.

The morphology, phase composition, roughness, hydrophilicity, and biocompatibility of P-PEIs were evaluated and compared with polyetherimide (PEI) and Ti6Al4V disks.

P-PEIs showed a biomimetic porous structure with a modulus of 78.95 ± 2.30 MPa.

The water contact angle of P-PEIs was 75.4 ± 3.39°, which suggested that P-PEIs had a wettability surface.

Moreover, P-PEIs provides a feasible environment for cell adhesion and proliferation.

The relative cell adhesion capability and the cell morphology on P-PEIs were better than PEI and Ti6Al4V samples.

Furthermore, the MC3T3-E1 cells on P-PEIs showed faster proliferation rate than other groups.

It was revealed that the P-PEIs could be a potential material for the application of bone regeneration.