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Alteration of Mevalonate Pathway in Rat Splenic Lymphocytes: Possible Role in Cytokines Secretion Regulated by L-Theanine
Joint Authors
Tan, Z. L.
Li, Chengjian
Yan, Qiongxian
Tang, Shaoxun
Xiao, Wenjun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
L-Theanine is a nonprotein amino acid in tea, and its immunomodulatory function has been confirmed.
This study aimed to investigate the effect of L-theanine addition on cytokines secretion in rat splenic lymphocytes and explore its potential immunomodulatory effects on the mevalonate biosynthetic pathway.
Our results showed that L-theanine treatment did not influence the proliferation and division indexes of the splenic lymphocytes subsets.
Interestingly, L-theanine treatment had regulated the contents of IFN-γ, IL-2, IL-4, IL-10, IL-12, and TNF-α (P<0.001) except IL-6 and upregulated the mRNA and protein expression of Ras-related protein Rap-1A (Rap1A), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), and farnesyl diphosphate synthase (FDPs) (P<0.001).
Additionally, there was a positive correlation between Rap1A and HMGCR proteins expression and IFN-γ, IL-4, and IL-6 levels.
In conclusion, L-theanine regulated the secretion of cytokines probably by activating expression of Rap1A and HMGCR proteins involved in the mevalonate biosynthetic pathway in rat splenic lymphocytes.
Therefore, L-theanine might be a promising potential drug candidate as immunopotentiator.
American Psychological Association (APA)
Li, Chengjian& Yan, Qiongxian& Tang, Shaoxun& Xiao, Wenjun& Tan, Z. L.. 2018. Alteration of Mevalonate Pathway in Rat Splenic Lymphocytes: Possible Role in Cytokines Secretion Regulated by L-Theanine. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1124380
Modern Language Association (MLA)
Li, Chengjian…[et al.]. Alteration of Mevalonate Pathway in Rat Splenic Lymphocytes: Possible Role in Cytokines Secretion Regulated by L-Theanine. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1124380
American Medical Association (AMA)
Li, Chengjian& Yan, Qiongxian& Tang, Shaoxun& Xiao, Wenjun& Tan, Z. L.. Alteration of Mevalonate Pathway in Rat Splenic Lymphocytes: Possible Role in Cytokines Secretion Regulated by L-Theanine. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1124380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124380