α-1-Acid Glycoprotein Concentration as an Outcome Predictor in Adult Patients with Sepsis

Joint Authors

Lin, Wei-Che
Wang, Hung-Chen
Chiang, Yi-Fang
Cheng, Ben-Chung
Lu, Cheng-Hsien
Huang, Chih-Cheng
Ko, Jih-Yang
Hsiao, Sheng-Yuan
Lai, Yun-Ru
Kung, Chia-Te
Tsai, Nai-Wen
Su, Yu-Jih
Su, Chih-Min

Source

BioMed Research International

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-06-12

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Medicine

Abstract EN

Background.

α-1-Acid glycoprotein (AGP) is an acute-phase protein that plays a role in first-line defense against infection and is therefore elevated in sepsis.

We tested the hypothesis that AGP levels increase initially in sepsis and decrease after antimicrobial therapy and that these levels may predict treatment outcomes.

Methods.

AGP, biomarkers widely used in clinical practice, and maximum 24-h acute physiology and chronic health evaluation (APACHE)-II scores upon emergency department (ED) admission were prospectively evaluated and compared.

We further examined changes in AGP concentrations 1, 4, and 7 days after admission and determined the value of AGP that may be used to accurately and reliably predict the prognosis in patients with sepsis.

Results.

Mechanical ventilation, white blood cell (WBC) counts, C-reactive protein (CRP) and lactate levels, maximum 24-h APACHE-II scores, and AGP concentrations were significantly higher upon admission in patients with sepsis who died.

AGP and lactate concentrations were also significantly higher in non-survivors than in survivors on days 1, 4, and 7.

As indicated by the stepwise logistic regression model analysis and area under the curve analysis, AGP was the best prognostic indicator, and the cut-off value for predicting fatality was 1307 μg/mL, and any increase 1-ng/mL in AGP concentration would increase the fatality rate by 0.5%.

Conclusion.

Based on our observations, AGP may be a good prognostic predictor in patients with sepsis.

In addition, serial AGP levels meet the requirements for predicting outcomes in patients with sepsis.

American Psychological Association (APA)

Hsiao, Sheng-Yuan& Lai, Yun-Ru& Kung, Chia-Te& Tsai, Nai-Wen& Su, Chih-Min& Huang, Chih-Cheng…[et al.]. 2019. α-1-Acid Glycoprotein Concentration as an Outcome Predictor in Adult Patients with Sepsis. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1124421

Modern Language Association (MLA)

Hsiao, Sheng-Yuan…[et al.]. α-1-Acid Glycoprotein Concentration as an Outcome Predictor in Adult Patients with Sepsis. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1124421

American Medical Association (AMA)

Hsiao, Sheng-Yuan& Lai, Yun-Ru& Kung, Chia-Te& Tsai, Nai-Wen& Su, Chih-Min& Huang, Chih-Cheng…[et al.]. α-1-Acid Glycoprotein Concentration as an Outcome Predictor in Adult Patients with Sepsis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1124421

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1124421