The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance
Joint Authors
Wang, Hui-Min
Kang, Wenyi
Xu, Xiaoqing
Saadeldeen, Fatma S. A.
Xu, Lanting
Zhao, Yingying
Wei, Jinfeng
Liu, Zhenhua
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Three lignans, phillyrin, forsythia ester A, and rosin-β-D-furan glucose, were isolated from Forsythia suspensa which is a famous Traditional Chinese Medicine used for clearing heat and detoxifying, reducing swelling and dispersing knot, and dispersing wind heat.
In this study, the effects of phillyrin, forsythia ester A, and rosin-β-D-furan glucose on insulin resistance of 3T3-L1 adipocytes were investigated by the method of glucose oxidase-peroxidase (GOD-POD) and the mechanism was assayed by the method of western blot.
The results indicated that phillyrin, forsythia ester A, and rosin-β-D-furan glucose could improve the glucose uptake in 3T3-L1 adipocytes under insulin resistance (IR).
Among them, phillyrin showed significant activity in increasing glucose consumption at the concentrations of 100 μM and 200 μM (P < 0.001).
The mechanism of improving insulin resistance may be that phillyrin could raise the protein phosphorylation of IRS-1 and Akt and the expression levels of GLUT4 protein.
American Psychological Association (APA)
Xu, Xiaoqing& Saadeldeen, Fatma S. A.& Xu, Lanting& Zhao, Yingying& Wei, Jinfeng& Wang, Hui-Min…[et al.]. 2019. The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1124431
Modern Language Association (MLA)
Xu, Xiaoqing…[et al.]. The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1124431
American Medical Association (AMA)
Xu, Xiaoqing& Saadeldeen, Fatma S. A.& Xu, Lanting& Zhao, Yingying& Wei, Jinfeng& Wang, Hui-Min…[et al.]. The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1124431
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124431