Antioxidant, Anti-Inflammatory, and Antitumoral Effects of Aqueous Ethanolic Extract from Phoenix dactylifera L. Parthenocarpic Dates
Joint Authors
Marrakchi, Naziha
El Abed, Hanen
Chakroun, Mouna
Abdelkafi-Koubaa, Zaineb
Drira, Noureddine
Mejdoub, Hafedh
Khemakhem, Bassem
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of this study was to evaluate the antioxidant, the anti-inflammatory, and the antitumoral activities of the aqueous ethanolic extract from Phoenix dactylifera L.
parthenocarpic dates.
The antioxidant activity was carried using DPPH radical scavenging activity.
The result showed that parthenocarpic dates had strongly scavenging activity on DPPH reaching 94% with an IC50 value of 0.15 ± 0.011 mg/mL (p < 0.05).
The anti-inflammatory potential was determined by the inhibitory effect of the aqueous ethanolic extract on phospholipase A2 activity as well as on carrageenan-induced paw oedema in mice.
The in vitro study showed that the extract inhibited the phospholipase A2 activity with an IC50 value of 130 μg/mL and the in vivo study showed a significantly decrease in the paw oedema after 1 h compared to the control group.
Finally, the antiproliferative activity of the aqueous ethanolic extract was assessed by MTT test against MCF-7 and MDA-MB-231 cancer cell lines.
This extract was effective in inhibiting MDA-MB-231 and MCF-7 cancer cells growth with IC50 values of 8 and 18 mg/mL, respectively, after 72 h treatment.
These results confirm the ethnopharmacological significance of Phoenix dactylifera L.
parthenocarpic dates, which could add support for its pharmaceutical use.
American Psychological Association (APA)
El Abed, Hanen& Chakroun, Mouna& Abdelkafi-Koubaa, Zaineb& Drira, Noureddine& Marrakchi, Naziha& Mejdoub, Hafedh…[et al.]. 2018. Antioxidant, Anti-Inflammatory, and Antitumoral Effects of Aqueous Ethanolic Extract from Phoenix dactylifera L. Parthenocarpic Dates. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1124451
Modern Language Association (MLA)
El Abed, Hanen…[et al.]. Antioxidant, Anti-Inflammatory, and Antitumoral Effects of Aqueous Ethanolic Extract from Phoenix dactylifera L. Parthenocarpic Dates. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1124451
American Medical Association (AMA)
El Abed, Hanen& Chakroun, Mouna& Abdelkafi-Koubaa, Zaineb& Drira, Noureddine& Marrakchi, Naziha& Mejdoub, Hafedh…[et al.]. Antioxidant, Anti-Inflammatory, and Antitumoral Effects of Aqueous Ethanolic Extract from Phoenix dactylifera L. Parthenocarpic Dates. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1124451
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124451