Effect of Coenzyme Q10 on Insulin Resistance in Korean Patients with Prediabetes: A Pilot Single-Center, Randomized, Double-Blind, Placebo-Controlled Study
Joint Authors
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
This study aimed to examine whether administration of coenzyme Q10, an antioxidant, improves insulin resistance in patients with prediabetes.
The study design was a pilot single-center, randomized, double-blind, placebo-controlled trial.
Methods.
This pilot single-center, randomized, double-blind, placebo-controlled trial included a total of 80 adults (aged ≥20 years) with impaired glucose tolerance.
After the initial screening visit, subjects were assigned to either the experimental (n = 40) or placebo (n = 40) group via simple randomization.
Insulin resistance was represented as the insulin resistance index estimated by homeostasis model assessment (HOMA-IR).
Results.
After the 8-week treatment period, the coenzyme group exhibited a significant decrease in the HOMA-IR (P < .001).
The free oxygen radical and coenzyme Q10 concentrations were found to correlate significantly (P < .001).
However, no significant changes in fasting blood glucose, insulin, and glycated hemoglobin levels were observed in either group.
Additionally, no adverse events occurred in either group.
Conclusion.
Patients with prediabetes who were administered coenzyme Q10 showed a significant reduction in HOMA-IR values.
Therefore, administration of coenzyme Q10 in patients with impaired glucose tolerance may slow the progression from prediabetes to overt diabetes.
American Psychological Association (APA)
Yoo, Ja-Young& Yum, Keun-Sang. 2018. Effect of Coenzyme Q10 on Insulin Resistance in Korean Patients with Prediabetes: A Pilot Single-Center, Randomized, Double-Blind, Placebo-Controlled Study. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1124507
Modern Language Association (MLA)
Yoo, Ja-Young& Yum, Keun-Sang. Effect of Coenzyme Q10 on Insulin Resistance in Korean Patients with Prediabetes: A Pilot Single-Center, Randomized, Double-Blind, Placebo-Controlled Study. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1124507
American Medical Association (AMA)
Yoo, Ja-Young& Yum, Keun-Sang. Effect of Coenzyme Q10 on Insulin Resistance in Korean Patients with Prediabetes: A Pilot Single-Center, Randomized, Double-Blind, Placebo-Controlled Study. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1124507
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124507