Bioactivities of Flavonoids from Lopezia racemosa
Joint Authors
Sánchez Arreola, Eugenio
Vergara Barragán, Enrique
Meza-Reyes, Socorro
Montiel-Smith, Sara
Bach, Horacio
Hernández, Luis R.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Lopezia racemosa Cav.
(Onagraceae) has been used in Mexican traditional medicine to alleviate stomachache, biliary colic, urine retention, stomach cancer, and skin, dental, buccal, and urinary infections.
The objective of this study was to determine the bioactivities of specific parts of the plant to scientifically confirm its traditional use.
Aerial parts and flowers were macerated and subsequently extracted with hexane, chloroform, and methanol.
This study was focused on the analysis of polar components, and thus the methanolic fractions were selected for further investigations.
These fractions were evaluated for their antimicrobial activity using a panel of bacterial Gram-positive and -negative strains, as well as fungal strains, including filamentous fungi and yeasts.
In addition, the cytotoxic activity of the extract was assessed by MTT using the human-derived monocytic THP-1 and the normal human fibroblast cell lines.
Various fractions showed antimicrobial activity against various pathogens, although the most relevant were against Pseudomonas aeruginosa and Trichophyton mentagrophytes.
No inhibition of yeasts was recorded.
Only four fractions showed cytotoxic effects when the human-derived THP-1 and fibroblast cells were assessed.
The four flavonoids isolated from the extract were luteolin, luteolin-6-C-hexoside, luteolin-8-C-hexoside, and hyperoside.
The biological activities presented in this study validate some traditional uses of the plant.
American Psychological Association (APA)
Vergara Barragán, Enrique& Bach, Horacio& Meza-Reyes, Socorro& Montiel-Smith, Sara& Sánchez Arreola, Eugenio& Hernández, Luis R.. 2019. Bioactivities of Flavonoids from Lopezia racemosa. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1124522
Modern Language Association (MLA)
Vergara Barragán, Enrique…[et al.]. Bioactivities of Flavonoids from Lopezia racemosa. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1124522
American Medical Association (AMA)
Vergara Barragán, Enrique& Bach, Horacio& Meza-Reyes, Socorro& Montiel-Smith, Sara& Sánchez Arreola, Eugenio& Hernández, Luis R.. Bioactivities of Flavonoids from Lopezia racemosa. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1124522
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124522