Genetic Variants in Group-Specific Component (GC) Gene Are Associated with Breast Cancer Risk among Chinese Women
Joint Authors
Su, Jian
Zhu, Zheng
van Duijnhoven, Fränzel
Chen, Fuxing
Dong, Meihua
Qian, Yun
Yu, Hao
Yang, Jie
Cui, Lan
Han, Renqiang
Du, Wencong
Zhou, Jinyi
Wu, Ming
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The group-specific component (GC) gene, one of the vitamin D pathway genes, seems to play an important role in cancer development.
A population-based breast cancer study including 818 cases and 935 controls in a Chinese population was carried out to evaluate the potential associations of four polymorphisms (rs16847024, rs17467825, rs2298850, and rs3755967) in the GC gene with risk of breast cancer.
We detected three SNPs with statistically significant effects on breast cancer development after adjusting for age, menopausal status, body mass index (BMI), family history of breast cancer, income, waist circumference, and education (rs17467825: adjusted OR = 0.80, 95% CI = 0.65–0.99; rs2298850: adjusted OR = 0.80, 95% CI = 0.65–0.98; rs3755967: adjusted OR = 0.80, 95% CI = 0.65–0.98).
Stratified analysis found that when an individual had a waist circumference <80 cm, rs17467825, rs2298850, and rs3755967 could markedly reduce the risk of breast cancer.
Significant interactions between polymorphisms of rs2298850 and rs3755967 and waist circumference were also observed for breast cancer risk.
Combined analysis revealed a significant association among the allele numbers of protective effects with decreased breast cancer risk (Ptrend=0.043).
These results indicated that, in the GC gene, genetic mutations might be related to breast cancer susceptibility in Chinese women.
American Psychological Association (APA)
Chen, Fuxing& Zhu, Zheng & van Duijnhoven, Fränzel& Dong, Meihua& Qian, Yun& Yu, Hao…[et al.]. 2019. Genetic Variants in Group-Specific Component (GC) Gene Are Associated with Breast Cancer Risk among Chinese Women. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1124539
Modern Language Association (MLA)
Chen, Fuxing…[et al.]. Genetic Variants in Group-Specific Component (GC) Gene Are Associated with Breast Cancer Risk among Chinese Women. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1124539
American Medical Association (AMA)
Chen, Fuxing& Zhu, Zheng & van Duijnhoven, Fränzel& Dong, Meihua& Qian, Yun& Yu, Hao…[et al.]. Genetic Variants in Group-Specific Component (GC) Gene Are Associated with Breast Cancer Risk among Chinese Women. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1124539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124539