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Prenatal Androgenization Induces Anxiety-Like Behavior in Female Rats, Associated with Reduction of Inhibitory Interneurons and Increased BDNF in Hippocampus and Cortex
Joint Authors
Macut, Djuro
Stanojlović, Olivera
Rankov Petrovic, Bojana
Hrncic, Dragan
Mladenovic, Dusan
Simic, Tatjana
Suvakov, Sonja
Jovanovic, Djurdja
Puskas, Nela
Zaletel, Ivan
Velimirovic, Milica
Cirkovic, Valentina
Rasic-Markovic, Aleksandra
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Anxiety is one of the most frequent psychiatric disorders.
Despite the fact that most studies describe an anxiolytic effect of testosterone, hyperandrogenemia in mothers is assumed to be related to an increased risk of mood disorders in their offspring.
An increasing body of scientific evidence suggests that an altered expression of interneuronal markers of the hippocampus may be the cause of anxiety.
The aim of this study was to examine the influence of maternal hyperandrogenemia on behavioral parameters of anxiety-like behavior, neuropeptide Y (NPY) and parvalbumin (PV) expression in the hippocampus, and the level of the brain-derived neurotrophic factor (BDNF) in the hippocampus and cerebral cortex.
Pregnant female Wistar albino rats were treated with testosterone undecanoate on the 20th day of gestation.
Anxiety-like behavior in adult female offspring was evaluated by the elevated plus maze test and the open field.
The number of PV and NPY immunoreactive cells in the hippocampus was determined immunohistochemically.
The level of BDNF expression in the hippocampus and cerebral cortex was analyzed with the Western blot test.
Prenatal hyperandrogenization increased anxiety-like behavior in female offspring and decreased expression of NPY+ and PV+ in the CA1 region of the hippocampus as compared to the control group.
BDNF expression in the hippocampus and cerebral cortex of prenatally androgenized female offspring was significantly increased in comparison with the controls.
Prenatal hyperandrogenization may be the cause of anxiety-like behavior in female offspring.
Decrease in NPY and PV expression in the hippocampus may explain the possible mechanism of hyperandrogenization induced anxiety.
American Psychological Association (APA)
Rankov Petrovic, Bojana& Hrncic, Dragan& Mladenovic, Dusan& Simic, Tatjana& Suvakov, Sonja& Jovanovic, Djurdja…[et al.]. 2019. Prenatal Androgenization Induces Anxiety-Like Behavior in Female Rats, Associated with Reduction of Inhibitory Interneurons and Increased BDNF in Hippocampus and Cortex. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1124557
Modern Language Association (MLA)
Rankov Petrovic, Bojana…[et al.]. Prenatal Androgenization Induces Anxiety-Like Behavior in Female Rats, Associated with Reduction of Inhibitory Interneurons and Increased BDNF in Hippocampus and Cortex. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1124557
American Medical Association (AMA)
Rankov Petrovic, Bojana& Hrncic, Dragan& Mladenovic, Dusan& Simic, Tatjana& Suvakov, Sonja& Jovanovic, Djurdja…[et al.]. Prenatal Androgenization Induces Anxiety-Like Behavior in Female Rats, Associated with Reduction of Inhibitory Interneurons and Increased BDNF in Hippocampus and Cortex. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1124557
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124557