Dihydroartemisinin Promotes the Osteogenesis of Human Mesenchymal Stem Cells via the ERK and Wntβ-Catenin Signaling Pathways
Joint Authors
Ni, Licheng
Kuang, Zhihui
Gong, Zhe
Xue, Deting
Zheng, Qiang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Dihydroartemisinin (DHA), which is considered to be one of the active compounds within Artemisia annua, has extensively been used in recent years as the most effective drug against malaria, having many biological functions including anticancer, antifungal, and immunomodulatory activities.
However, DHA plays a role in the regulation of the proliferation and human mesenchymal stem cells (hMSCs) osteogenic differentiation that remains unknown.
We explored DHA’s effect on hMSCs’ proliferation as well as the osteogenic differentiation, together with its underlying mechanisms of action.
We showed that DHA enhanced osteogenic differentiation but had no significant effect on hMSCs’ proliferation.
It probably exerted its functions through the signaling pathways of ERK1/2 as well as Wnt/β.
Because DHA has low toxicity and costs, it might be regarded as an important drug for fracture treatment and tissue engineering.
American Psychological Association (APA)
Ni, Licheng& Kuang, Zhihui& Gong, Zhe& Xue, Deting& Zheng, Qiang. 2019. Dihydroartemisinin Promotes the Osteogenesis of Human Mesenchymal Stem Cells via the ERK and Wntβ-Catenin Signaling Pathways. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1124574
Modern Language Association (MLA)
Ni, Licheng…[et al.]. Dihydroartemisinin Promotes the Osteogenesis of Human Mesenchymal Stem Cells via the ERK and Wntβ-Catenin Signaling Pathways. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1124574
American Medical Association (AMA)
Ni, Licheng& Kuang, Zhihui& Gong, Zhe& Xue, Deting& Zheng, Qiang. Dihydroartemisinin Promotes the Osteogenesis of Human Mesenchymal Stem Cells via the ERK and Wntβ-Catenin Signaling Pathways. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1124574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124574