Advantages of Graphene Biosensors for Human Stem Cell Therapy Potency Assays
Joint Authors
Burns, Jorge S.
Amărandi, Roxana-Maria
Becheru, Diana F.
Vlăsceanu, George M.
Ioniță, Mariana
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Regenerative medicine is challenged by the need to conform to rigorous guidelines for establishing safe and effective development and translation of stem cell-based therapies.
Counteracting widespread concerns regarding unproven cell therapies, stringent cell-based assays seek not only to avoid harm but also to enhance quality and efficacy.
Potency indicates that the cells are functionally fit for purpose before they are administered to the patient.
It is a paramount quantitative critical quality attribute serving as a decisive release criterion.
Given a broad range of stem cell types and therapeutic contexts the potency assay often comprises one of the most demanding hurdles for release of a cell therapy medicinal product.
With need for improved biomarker assessment and expedited measurement, recent advances in graphene-based biosensors suggest that they are poised to be valuable platforms for accelerating potency assay development.
Among several potential advantages, they offer versatility for sensitive measurement of a broad range of potential biomarker types, cell biocompatibility for direct measurement, and small sample sufficiency, plus ease of use and point-of-care applicability.
American Psychological Association (APA)
Amărandi, Roxana-Maria& Becheru, Diana F.& Vlăsceanu, George M.& Ioniță, Mariana& Burns, Jorge S.. 2018. Advantages of Graphene Biosensors for Human Stem Cell Therapy Potency Assays. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1124575
Modern Language Association (MLA)
Amărandi, Roxana-Maria…[et al.]. Advantages of Graphene Biosensors for Human Stem Cell Therapy Potency Assays. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1124575
American Medical Association (AMA)
Amărandi, Roxana-Maria& Becheru, Diana F.& Vlăsceanu, George M.& Ioniță, Mariana& Burns, Jorge S.. Advantages of Graphene Biosensors for Human Stem Cell Therapy Potency Assays. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1124575
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124575