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Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats
Joint Authors
Chen, Yuxin
Zhou, Ziping
Mo, Qigui
Zhou, Gao
Wang, Youwei
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-02
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Dimethylnitrosamine (DMN) is a potent hepatotoxin, carcinogen, and mutagen.
In our previous study, a candidate gallic acid (GA) that widely exists in food and fruit was selected for its capability to alleviate DMN toxicity in vivo.
We aimed to investigate the therapeutic potential of GA against DMN-induced liver fibrosis.
During the first four weeks, DMN was administered to rats via intraperitoneal injection every other day, except the control group.
GA or silymarin was given to rats by gavage once daily from the second to the sixth week.
GA significantly reduced liver damage in serum parameters and improved the antioxidant capacity in liver and kidney tissues.
Cytokines involved in liver fibrosis were measured at transcriptional and translational levels.
These results indicate that GA exhibits robust antioxidant and antifibrosis effects and may be an effective candidate natural medicine for liver fibrosis treatment.
American Psychological Association (APA)
Chen, Yuxin& Zhou, Ziping& Mo, Qigui& Zhou, Gao& Wang, Youwei. 2018. Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats. BioMed Research International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1124580
Modern Language Association (MLA)
Chen, Yuxin…[et al.]. Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats. BioMed Research International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1124580
American Medical Association (AMA)
Chen, Yuxin& Zhou, Ziping& Mo, Qigui& Zhou, Gao& Wang, Youwei. Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1124580
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124580