Tranexamic Acid for Adults with Melasma: A Systematic Review and Meta-Analysis
Joint Authors
Zhang, Lei
Tan, Wei-Qiang
Fang, Qing-Qing
Zhao, Wan-Yi
Zhao, Qi-Ming
Gao, Jie
Wang, Xiao-Wei
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Objective.
Melasma is a highly prevalent, chronic, and pigmentary disorder.
This systematic review aims to evaluate the efficacy and safety of tranexamic acid (TA) for the treatment of adults with melasma.
Methods.
We independently searched 3 databases from beginning to 26 April, 2018.
The study included 21 eligible trials.
Two writers extracted data at the same time independently.
Study outcomes were calculated by standardized mean differences (SMD) with 95% confidence intervals (CIs).
All statistical analyses were performed using Review Manager Version 5.3 and STATA Version 15.1.
Results.
The combined results showed that the use of TA was associated with reduced Melasma Area and Severity Index (MASI) and Melanin Index (MI).
No significant difference in Erythema Index (EI) was observed with TA treatment.
Side effects were minor, with a few cases reporting mild gastrointestinal reaction, oligomenorrhoea, hypopigmentation, urticarial rash, and skin irritation xerosis.
Conclusion.
The meta-analysis suggested that TA treatment appeared to be a promising therapeutic approach for melasma.
American Psychological Association (APA)
Zhang, Lei& Tan, Wei-Qiang& Fang, Qing-Qing& Zhao, Wan-Yi& Zhao, Qi-Ming& Gao, Jie…[et al.]. 2018. Tranexamic Acid for Adults with Melasma: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1124585
Modern Language Association (MLA)
Zhang, Lei…[et al.]. Tranexamic Acid for Adults with Melasma: A Systematic Review and Meta-Analysis. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1124585
American Medical Association (AMA)
Zhang, Lei& Tan, Wei-Qiang& Fang, Qing-Qing& Zhao, Wan-Yi& Zhao, Qi-Ming& Gao, Jie…[et al.]. Tranexamic Acid for Adults with Melasma: A Systematic Review and Meta-Analysis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1124585
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124585