![](/images/graphics-bg.png)
Vitamin D as a Principal Factor in Mediating Rheumatoid Arthritis-Derived Immune Response
Joint Authors
Kamboh, M. Ilyas
Bhatti, Attya
Aslam, Muhammad M.
John, Peter
Jahangir, Sidrah
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is a systemic multifactorial autoimmune disorder.
The interactions between diverse environmental and genetic factors lead to the onset of this complex autoimmune disorder.
Serum levels of vitamin D (VD) are involved in the regulation of various immune responses.
Vitamin D is a key signaling molecule in the human body that maintains calcium as well as phosphate homeostasis.
It also regulates the functions of the immune system and, thus, can play a substantial role in the etiology of various autoimmune disorders, including RA.
Low serum VD levels have been found to be associated with a higher risk of RA, although this finding has not been replicated consistently.
The molecular mechanisms by which VD influences autoimmunity need to be further explored to understand how variation in plasma VD levels could affect the pathogenesis of RA.
This mini-review focuses on the influence of VD and its serum levels on RA susceptibility, RA-associated complexities, treatment, and transcriptome products of key proinflammatory cytokines, along with other cytokines that are key regulators of inflammation in rheumatoid joints.
American Psychological Association (APA)
Aslam, Muhammad M.& John, Peter& Bhatti, Attya& Jahangir, Sidrah& Kamboh, M. Ilyas. 2019. Vitamin D as a Principal Factor in Mediating Rheumatoid Arthritis-Derived Immune Response. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1124615
Modern Language Association (MLA)
Aslam, Muhammad M.…[et al.]. Vitamin D as a Principal Factor in Mediating Rheumatoid Arthritis-Derived Immune Response. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1124615
American Medical Association (AMA)
Aslam, Muhammad M.& John, Peter& Bhatti, Attya& Jahangir, Sidrah& Kamboh, M. Ilyas. Vitamin D as a Principal Factor in Mediating Rheumatoid Arthritis-Derived Immune Response. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1124615
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124615