Immune Escape Mechanisms and Future Prospects for Immunotherapy in Neuroblastoma
Joint Authors
Hongeng, Suradej
Vanichapol, Thitinee
Chutipongtanate, Somchai
Anurathapan, Usanarat
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Neuroblastoma (NB) is the most common extracranial solid tumor in childhood with 5-year survival rate of 40% in high-risk patients despite intensive therapies.
Recently, adoptive cell therapy, particularly chimeric antigen receptor (CAR) T cell therapy, represents a revolutionary treatment for hematological malignancies.
However, there are challenges for this therapeutic strategy with solid tumors, as a result of the immunosuppressive nature of the tumor microenvironment (TME).
Cancer cells have evolved multiple mechanisms to escape immune recognition or to modulate immune cell function.
Several subtypes of immune cells that infiltrate tumors can foster tumor development, harbor immunosuppressive activity, and decrease an efficacy of adoptive cell therapies.
Therefore, an understanding of the dual role of the immune system under the influences of the TME has been crucial for the development of effective therapeutic strategies against solid cancers.
This review aims to depict key immune players and cellular pathways involved in the dynamic interplay between the TME and the immune system and also to address challenges and prospective development of adoptive T cell transfer for neuroblastoma.
American Psychological Association (APA)
Vanichapol, Thitinee& Chutipongtanate, Somchai& Anurathapan, Usanarat& Hongeng, Suradej. 2018. Immune Escape Mechanisms and Future Prospects for Immunotherapy in Neuroblastoma. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1124656
Modern Language Association (MLA)
Vanichapol, Thitinee…[et al.]. Immune Escape Mechanisms and Future Prospects for Immunotherapy in Neuroblastoma. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1124656
American Medical Association (AMA)
Vanichapol, Thitinee& Chutipongtanate, Somchai& Anurathapan, Usanarat& Hongeng, Suradej. Immune Escape Mechanisms and Future Prospects for Immunotherapy in Neuroblastoma. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1124656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124656